Immune Responses in Animal Models
Animal models have made major contributions to our understanding of the nature of the immune response to tuberculosis. Although each of the most popular models tend to give us a different perspective of the disease process, the collective information gained has given us considerable insight into the basis of susceptibility and resistance to disease as well as the nature of both protective immunity and immunopathology.
KeywordsNatural Killer Cell Mycobacterium Tuberculosis Tuberculosis Infection Mycobacterium Tuberculosis Infection Phagosomal Membrane
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- Anderson P (1994) Effective vaccination of mice against Mycobacterium tuberculosis infection with a soluble mixture of secreted mycobacterial proteins. Infect Immun 62: 2536–2544Google Scholar
- Augustin A, Kubo RT, Sim G (1989) Resident pulmonary lymphocytes expressing the yS receptor.Nature 340: 239–241Google Scholar
- Chatterjee D, Hunter SW, McNeil M, Brennan PJ (1992a) Lipoarabinomannan. Multiglycosylated form of the mycobacterial mannosylphophatidylinositols. J Biol Chem 267: 6228–6233Google Scholar
- Chatterjee D, Lowell K, Rivoire B, McNeil M, Brennan PJ (1992b) Lipoarabinomannan of Mycobacterium tuberculosis. Capping with mannosyl residues in some strains. J Biol Chem 267: 6234–6239Google Scholar
- Chatterjee D, Khoo K-H, McNeil MR, Dell A, Morris HR, Brennan PJ (1993) Structural definition of the non-reducing termini of mannose-capped LAM from Mycobacterium tuberculosis through selective enzymatic degradation and fast atom bombardment-mass spectrometry. Glycobiology 3: 497–506PubMedCrossRefGoogle Scholar
- Dalton D, Pitts-Meek S, Keshav S, Figari IS, Bradley A, Stewart TA (1993) Multiple defects of immune cell function in mice with disrupted interferon y genes Science 259: 1739–1742Google Scholar
- Graur D, Hide WA, Wen-Hsiung (1991) Is the guinea pig a rodent? Nature 351: 649–652Google Scholar
- Izzo AA, North RJ (1992) Evidence for an a T-cell independent mechanism of resistance to Mycobacteria. Bacillus calmette-guerin causes progressive infection in severe combined immunodeficient mice, but not in nude mice or in mice depleted of CD4+ and CD8+ T-cells. J Exp Med 176: 581–586 PubMedCrossRefGoogle Scholar
- McMurray DN (1994) Guinea pig model of tuberculosis. In: Bloom BR (ed) Tuberculosis: pathogenesis, protection, and control. ASM, Washington DC, pp 135–147Google Scholar
- Prinzis S. Chatterjee D, Brennan PJ (1993) Structure and antigenicity of lipoarabinomannan from Mycobacterium bovis BCG. J Gen Microbic)! 139: 649–2658Google Scholar