Tuberculosis pp 97-130 | Cite as

In Vitro Interaction of Mycobacterium tuberculosis and Macrophages: Activation of Anti-mycobacterial Activity of Macrophages and Mechanisms of Anti-mycobacterial Activity

  • L. O’Brien
  • B. Roberts
  • P. W. Andrew
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 215)


Mycobacterium tuberculosis is an example of a facultative intracellular pathogen which will survive and multiply within macrophages from non-immune individuals. It is a central tenet of cell-mediated immunity to intracellular pathogens that macrophages are the principal effector cells and that, after exposure to products of specifically sensitized T cells, they acquire the ability to kill these pathogens (Mackaness 1968). Much of the basic data on which the idea of cell-mediated immunity is founded came from studies on immunity to mycobacterial infections (Lurie 1942; Suter 1953; Mackaness 1964, 1968).


Mycobacterium Tuberculosis Respiratory Burst Murine Macrophage Human Macrophage Mycobacterium Avium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • L. O’Brien
    • 1
  • B. Roberts
    • 1
  • P. W. Andrew
    • 1
  1. 1.Department of Microbiology and ImmunologyUniversity of LeicesterLeicesterUK

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