Tuberculosis pp 97-130 | Cite as

In Vitro Interaction of Mycobacterium tuberculosis and Macrophages: Activation of Anti-mycobacterial Activity of Macrophages and Mechanisms of Anti-mycobacterial Activity

  • L. O’Brien
  • B. Roberts
  • P. W. Andrew
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 215)

Abstract

Mycobacterium tuberculosis is an example of a facultative intracellular pathogen which will survive and multiply within macrophages from non-immune individuals. It is a central tenet of cell-mediated immunity to intracellular pathogens that macrophages are the principal effector cells and that, after exposure to products of specifically sensitized T cells, they acquire the ability to kill these pathogens (Mackaness 1968). Much of the basic data on which the idea of cell-mediated immunity is founded came from studies on immunity to mycobacterial infections (Lurie 1942; Suter 1953; Mackaness 1964, 1968).

Keywords

Peroxide Superoxide Nitrite Arginine NADPH 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • L. O’Brien
    • 1
  • B. Roberts
    • 1
  • P. W. Andrew
    • 1
  1. 1.Department of Microbiology and ImmunologyUniversity of LeicesterLeicesterUK

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