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Mechanisms of Drug Resistance in Mycobacterium tuberculosis

  • Chapter
Tuberculosis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 215))

Abstract

Fifty years ago Selman Waksman and his colleagues discovered streptomycin and, for the first time, provided a chemotherapeutical approach to tuberculosis treatment as an alternative to fresh air, diet and physical exercise. Soon after the initiation of the chemotherapy era with streptomycin it was recognized that not all cases of tuberculosis could be cured due to the emergence of resistant mutants (Mitchison 1950). In the following years many other drugs were discovered, some of them too toxic for clinical use, but others like isoniazid, pyrazinamide, ethambutol or rifampin were very active (Forbes et al. 1965; Fox 1951; Tsukamura et al. 1958; Yeager et al. 1952), and physicians realised that the association of several drugs given simultaneously prevented the emergence of resistant mutants (American Thoracic Society 1986; O’Brien 1993). When tuberculosis results from infection with drug susceptible strains of M. tuberculosis, the success rate of short course chemotherapy is close to 100% provided that the regimen is strictly adhered to by both the physician and the patient (American Thoracic Society 1992; Grosset 1989; Hopewell 1994; Iseman 1994; Iseman et al. 1993).

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Author information

Authors and Affiliations

  1. Hôpital Ambroise Paré, 9, avenue Charles de Gaulle, 92104, Boulogne Cedex, France

    B. Heym

  2. Institut Pasteur, Unité de Génétique Moléculaire Bactérienne, 28 rue du Docteur Roux, 75724, Paris Cedex 15, France

    W. Philipp & S. T. Cole

Authors
  1. B. Heym
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  2. W. Philipp
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  3. S. T. Cole
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Editor information

Editors and Affiliations

  1. Department of Health and Human Services, Immunology and Molecular Pathogenesis Section, Division of AIDS, STD and TB Laboratory Research, Centers for Disease Control and Prevention, 30333, Atlanta, GA, USA

    Thomas M. Shinnick Ph.D. (Chief) (Chief)

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© 1996 Springer-Verlag Berlin Heidelberg

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Heym, B., Philipp, W., Cole, S.T. (1996). Mechanisms of Drug Resistance in Mycobacterium tuberculosis . In: Shinnick, T.M. (eds) Tuberculosis. Current Topics in Microbiology and Immunology, vol 215. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80166-2_3

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  • DOI: https://doi.org/10.1007/978-3-642-80166-2_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80168-6

  • Online ISBN: 978-3-642-80166-2

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