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The Koch Phenomenon and the Immunopathology of Tuberculosis

  • Chapter
Tuberculosis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 215))

Abstract

Tuberculosis kills more than three million people every year, and the problem is rapidly increasing. This is paradoxical when we know that the immune response is perfectly capable of coping with this infection. Before the advent of HIV, only 5% of infected individuals developed disease, and perhaps another 5% did so when T cell function was compromised by old age, stress or protein malnutrition. Therefore 90% of the population was resistant under normal circumstances. Moreover the incidence in the suceptible 10% could be reduced by up to 80% by BCG vaccination in those countries in which the vaccine worked. Why then are we failing to control the rapid increase in tuberculosis?

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Authors and Affiliations

  1. Department of Bacteriology, University College London Medical School, Windeyer Building, 46 Cleveland Street, London, W1P 6DB, UK

    G. A. W. Rook & J. L. Stanford

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  1. G. A. W. Rook
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  2. J. L. Stanford
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  1. Department of Health and Human Services, Immunology and Molecular Pathogenesis Section, Division of AIDS, STD and TB Laboratory Research, Centers for Disease Control and Prevention, 30333, Atlanta, GA, USA

    Thomas M. Shinnick Ph.D. (Chief) (Chief)

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Rook, G.A.W., Stanford, J.L. (1996). The Koch Phenomenon and the Immunopathology of Tuberculosis. In: Shinnick, T.M. (eds) Tuberculosis. Current Topics in Microbiology and Immunology, vol 215. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80166-2_11

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