Tuberculosis pp 239-262 | Cite as

The Koch Phenomenon and the Immunopathology of Tuberculosis

  • G. A. W. Rook
  • J. L. Stanford
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 215)


Tuberculosis kills more than three million people every year, and the problem is rapidly increasing. This is paradoxical when we know that the immune response is perfectly capable of coping with this infection. Before the advent of HIV, only 5% of infected individuals developed disease, and perhaps another 5% did so when T cell function was compromised by old age, stress or protein malnutrition. Therefore 90% of the population was resistant under normal circumstances. Moreover the incidence in the suceptible 10% could be reduced by up to 80% by BCG vaccination in those countries in which the vaccine worked. Why then are we failing to control the rapid increase in tuberculosis?


Tuberculosis Patient Muramyl Dipeptide Mycobacterial Antigen Tuberculous Lesion Sick Euthyroid Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • G. A. W. Rook
    • 1
  • J. L. Stanford
    • 1
  1. 1.Department of BacteriologyUniversity College London Medical SchoolLondonUK

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