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Dynamic Interactions of the Gag Polyprotein

  • Chapter
Morphogenesis and Maturation of Retroviruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 214))

Abstract

It has been known for 20 years that all retroviruses possess a similar genetic organization and that a single gene product, the Gag protein, is responsible for directing particle assembly (DICKSON et al. 1984; COFFIN 1984). However it is only very recently that an understanding of how the Gag protein functions has begun to take shape. This chapter reviews recent efforts to understand the assembly and budding functions of the Gag protein with a primary focus on Rous sarcoma virus (RSV, a member of the avian sarcoma-leukosis virus group of oncoviruses) and the human immunodeficiency virus type 1 (HIV-1). These studies have shown that in spite of a striking divergence in amino acid sequences, the two viruses utilize fundamentally similar mechanisms to direct assembly and budding.

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  1. Department of Microbiology and Immunology, The Pennsylvania State University School of Medicine, Hershey, PA, 17033, USA

    R. C. Craven & L. J. Parent

  2. Department of Medicine, The Pennsylvania State University School of Medicine, Hershey, PA, 17033, USA

    L. J. Parent

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  1. R. C. Craven
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  1. Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie, Universität Hamburg, Martinistrasse 52, 20251, Hamburg, Germany

    Hans-Georg Kräusslich

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Craven, R.C., Parent, L.J. (1996). Dynamic Interactions of the Gag Polyprotein. In: Kräusslich, HG. (eds) Morphogenesis and Maturation of Retroviruses. Current Topics in Microbiology and Immunology, vol 214. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80145-7_3

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  • DOI: https://doi.org/10.1007/978-3-642-80145-7_3

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