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NO fördert Tumorwachstum durch Lymphozytensuppression — Versuche in vivo

  • G. H. Leder
  • M. Oppenheim
  • M. Rosenstein
  • R. Hoffman
  • M. T. Lotze
  • H. G. Beger
Conference paper
Part of the Langenbecks Archiv für Chirurgie book series (DTGESCHIR, volume I/96)

Zusammenfassung

Das Stickstoffmonoxidradikal (NO) wirkt in verschiedenen in vitro [1,2] und in vivo Modellen [3, 4] antitumoral. Andererseits hemmt es zytotoxische, für die immunologische Tumorabwehr wichtige Lymphozyten [5]. Epidemiologisch gilt es sogar als karzinomfördernd [6]. Die Gründe für diese gegensätzlichen Eigenschaften sind unklar. Wir untersuchten deshalb das Tumorwachstum in einem murinen Metastasenmodell unter Interleukin 2 (IL-2)- und Aminoguanidin-bedingter (AG) Beeinflussung von Lymphozytenaktivität und NO-Konzentration.

NO supports tumor growth by suppression of lymphocytes — experiments in vivo

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1996

Authors and Affiliations

  • G. H. Leder
    • 1
    • 2
    • 4
  • M. Oppenheim
    • 2
  • M. Rosenstein
    • 3
  • R. Hoffman
    • 2
  • M. T. Lotze
    • 2
  • H. G. Beger
    • 1
  1. 1.Chirurgische Klinik IUniv. UlmUlmDeutschland
  2. 2.Dept. of SurgeryUniversity of PittsburghPittsburghUSA
  3. 3.Dept. of Radiation OncologyUniversity of PittsburghPittsburghUSA
  4. 4.Chirurgische Klinik IUniv. UlmUlmDeutschland

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