Zusammenfassung
Das Stickstoffmonoxidradikal (NO) wirkt in verschiedenen in vitro [1,2] und in vivo Modellen [3, 4] antitumoral. Andererseits hemmt es zytotoxische, für die immunologische Tumorabwehr wichtige Lymphozyten [5]. Epidemiologisch gilt es sogar als karzinomfördernd [6]. Die Gründe für diese gegensätzlichen Eigenschaften sind unklar. Wir untersuchten deshalb das Tumorwachstum in einem murinen Metastasenmodell unter Interleukin 2 (IL-2)- und Aminoguanidin-bedingter (AG) Beeinflussung von Lymphozytenaktivität und NO-Konzentration.
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© 1996 Springer-Verlag Berlin · Heidelberg
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Leder, G.H., Oppenheim, M., Rosenstein, M., Hoffman, R., Lotze, M.T., Beger, H.G. (1996). NO fördert Tumorwachstum durch Lymphozytensuppression — Versuche in vivo. In: Beger, H.G., Birk, D., Staib, L., Pichlmayr, R., Seifert, J., Hartel, W. (eds) Chirurgisches Forum ’96 fur experimentelle und klinische Forschung. Langenbecks Archiv für Chirurgie, vol I/96. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80138-9_37
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DOI: https://doi.org/10.1007/978-3-642-80138-9_37
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