The Search for Additional Alzheimer’s Disease Genes
Alzheimer disease (AD) is a complex, heterogeneous, genetic disorder that has resisted most attempts to understand its genetic etiology. Fortunately, linkage analysis has proven to be both powerful and successful in unraveling the genetic components of AD. Three loci have been identified; the amyloid precursor protein (APP) on chromosome 21, a newly identified gene on chromosome 14 and the apolipoprotein E locus (APOE) on chromosome 19. These loci account for approximately one half of the genetic etiology of AD. We have undertaken a genomic screening effort to identify additional AD genetic effects. Using a multi-analytical approach we have examined over 175 marker loci for linkage with AD in a series of late-onset (onset after 60 years of age) families. The results of these analyses have shown three chromosomal regions that could potentially contain additional AD susceptibility loci. These regions of interest will be further evaluated using additional markers and AD families to confirm these initial findings.
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