Abstract
Functional and genetic studies of the γδ T cell receptor (TCR) have progressed in reverse order compared to the study of αβ T cells (reviewed by Raulet 1989). A wealth of information about the αβ T cell population and its function was available before the genes for the αβ TCR were cloned. Studies of the αβ TCR repertoire and gene expression then helped elucidate molecular mechanisms for generating diversity of the αβ T cell repertoire and the nature of antigen recognition by αβ T cells. However, the identification of a third TCR locus (γ), and the subsequent discovery that a fourth TCR chain (δ) was encoded by genes embedded within the TCR-α locus, led to the description of the γδ TCR expressed by a T cell subpopulation with no known function. Over the last 10 years, laboratories around the world have been trying to assign functional roles for T cells expressing the γδ TCR. Studies of mouse and human γδ T cells have revealed many interesting differences in the biology of γδ vs. αβ T cells, such as tissue distribution, repertoire restrictions, requirement for a thymus for their development, and lack of classical MHC restriction (for reviews see Allison 1993; Haas et al. 1993; Kronenberg 1994; Lefrancois and Puddington 1995).
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References
Alaibac M (1992) γδ T lymphocytes: relevance of the current studies to dermatology. Int J Dermatol 31: 157–159
Allison JP (1993) γδ T cell development. Curr Opin Immunol 5: 241–246
Arstila TP, Lassila O (1993) Androgen-induced expansion of the peripheral blood γδ T cell population in the chicken. J Immunol 151: 6627–6633
Arstila TP, Toivanen P, Lassila O (1993) Helper activity of CD4+4 T cells is required for the avian y6 T cell response. Eur J Immunol 23: 2034–2037
Arstila TP, Vainio O, Lassila O (1994) Evolutionarily conserved function of CD28 in αβ T cell activation. Scand J Immunol 40: 368–371
Banbura M, Webster RG, Cooper MD, Doherty PC (1991) Size and frequency characteristics of al3 and γδ T cells in the spleens of normal and cyclophosphamide-suppressed virus-infected chickens. Cell Immunol 136: 242–250
Bernot A, Auffray C (1991) Primary structure and ontogeny of an avian CD3 transcript. Proc Natl Acad Sci USA 88: 2550–2554
Bilsland CAG, Springer TA (1994) Cloning and expression of the chicken CD18 cDNA. J Leukoc Biol 55: 501–506
Boismenu R, Havran WL (1994) Modulation of epithelial cell growth by intraepithelial y5 T cells. Science 26: 1253–1255
Bonneville M, Janeway Jr CA, Ito K, Haser W, Ishida I, Nakanishi N, Tonegawa S (1988) Intestinal intraepithelial lymphocytes are a distinct set of γδ T cells. Nature 336: 479–481
Boom WH, Balaji KN, Nayak R, Tsukaguchi K, Chervenak KA (1994) Characterization of a 10–14 KDa protease-sensitive Mycobacterium tuberculosis-H37Ra antigen that stimulates γδ T cells. Infect Immun 62: 5511–5518
Bucy RP, Chen CH, Cihak J, Lösch U, Cooper MD (1988) Avian T cells expressing γδ receptors localize in the splenic sinusoids and the intestinal epithelium. J Immunol 141: 2200–2205
Bucy RP, Chen CH, Cooper MD (1989) Tissue localization and CD8 accessory molecule expression of T δ/8 cells in humans. J Immunol 142: 3045–3047
Bucy RP, Li J, Xu XY, Char D, Chen CH (1990) Effect of cyclosporin A on the ontogeny of different T cell sublineages in chickens. J Immunol 144: 3257–3265
Cerf-Bensussan N, Jerry A, Brousse N, Lisowska-Grospierre B, Guy-Grand D, Gricelli C (1987) A monoclonal antibody (HML-1) defining a novel membrane molecule present on human intestinal lymphocytes. Eur J Immunol 17: 1279–1285
Chai J-Y, Lillehoj HS (1988) Isolation and functional characterization of chicken intestinal intra-epithelial lymphocytes showing natural killer cell activity against tumour target cells. Immunology 63: 111–117
Chan MM, Chen CH, Ager LL. Cooper MD (1988) Identification of the avian homologues of mammalian CD4 and CD8 antigens. J Immunol 140: 2133–2038
Chen CH, Ager LL, Gartland GL, Cooper MD (1986) Identification of a T3/T cell receptor complex in chickens. J Exp Med 164: 375–380
Chen CH, Cihak J, Lösch U, Cooper MD (1988) Diffferential expression of two T cell receptors, TCR1 and TCR2, on chicken lymphocytes. Eur J Immunol 18: 539–543
Chen CH, Sowder JT, Lahti JM, Cihak J, Lösch U, Cooper MD (1989) TCR3: a third T-cell receptor in the chicken. Proc Natl Acad Sci USA 86: 2351–2355
Chen CH, Pickel JM, Lahti JM, Cooper MD (1991) Surface markers on avian immune cells. In: Sharma JM (ed) Avian cellular immunology. CRC Press, Boca Raton, pp 2–22
Chow LM, Ratcliffe KJ, Veillette A(1992) Tkl is the avian homolog of the mammalian Icktyrosine protein kinase gene. Mol Cell Biol 12: 1226–1233
Cihak J, Hoffman-Fezer G, Ziegler-Heibrock HWL, Stein H, Kaspers B, Chen CH, Cooper MD, Lösch U (1991)T cells expressing the Vß1 T-cell receptor are required for IgA production in the chicken. Proc Natl Acad Sci USA 88: 10951–10955
Cihak J, Lösch U, Hoffmann-Fezer F, Chen CH, Cooper MD, Ziegler-Heitbrock HWL (1993) In vivo depletion of chicken T-cell subsets. Scand J Immunol 38: 123–129
Constant P, Davodeau F, Peyrat M-A, Poquet Y, Puzo G, Bonneville M, Fournie J-J (1994) Stimulation of human yö T cells by nonpeptidic mycobacterial ligands. Science 264–270
Cooper MD, Chen CH, Bucy RP, Thompson CB (1991) Avian T cell ontogeny. Adv Immunol 50: 87–117
Davidson NJ, Boyd RL (1992) Delineation of chicken thymocytes by CD3-TCR complex, CD4 and CD8 antigen expression reveals phylogenically conserved and novel thymocyte subsets. Int Immunol 4: 1175–1182
Davidson NJ, Chen CH, Boyd RL (1992) Kinetics of chicken embryonic thymocyte development in vivo and in organ culture. Eur J Immunol 22: 1429–1435
Dunon D, Cooper MD, Imhof BA (1993a) Thymic origin of embryonic γδT cells. J Exp Med 177: 257–263
Dunon D, Cooper MD, Imhof BA (1993b) Migration patterns of thymus-derivedyö T cells during chicken development. Eur J Immunol 23: 2545–2550
DuPasquier L (1989) Evolution of the immune sγδtem. In: Paul WE (ed) Fundamental immunology. Raven, New York, pp 139–165
Eichelberger M, Doherty PC (1994) γδ T cells from influenza-infected mice develop a natural killer cell phenotype following culture. Cell Immunol 159: 94–102
Fedecka-Bruner B, Penninger J, Vaigot P, Lehmann A, Martinez C, Kroemer G (1991) Developmental expression of IL-2-receptor light chain (CD25) in the chicken embryo. Dev Immunol 1: 237–242
Fichtelius KE, Finstad J, Good RA (1969) The phylogenetic occurrence of lymphocytes within the gut epithelium. Int Arch Allergy Appl Immunol 35: 119–133
Fujihashi K, Taguchi T, Aicher WK, McGhee JR, Bluestone JA, Eldridge JH, Kiyono H (1992) Immunoregulatory functions for murine intraepithelial lymphocytes; γδ T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while αβ TCR’ T cells provide B cell help. J Exp Med 175: 695–707
George JF, Cooper MD (1990) γδ T cells and αβ T cells differ in their developmental patterns of receptor expression and modulation requirements. Eur J Immunol 20: 2177–2181
Gershwin ME, Abplanalp H, Castles JJ, Ikeda RM, van der Water J, Eklund J, Haynes D (1981) Characterization of a spontaneous disease of White Leghorn chickens resembling progressive sγδtematic sclerosis (scleroderma). J Exp Med 153: 1640–1659
Goodman T, Lefrancois L (1988) Expression of the gamma/delta T-cell receptor on intestinal CD8’ intraepithelial lymphocytes. Nature 333: 855–858
Gruschwitz MS, Moorman S, Kromer G, Sgonc R, Dietrich H, Boeck G, Gershwin ME, Boyd R, Wick G (1991) Phenotypic analγδis of skin infiltrates in comparison with peripheral blood lymphocytes, spleen cells and thymocytes in early avian scleroderma. J. Autoimmun 4: 577–593
Guy-Grande D, Vassilla P (1993) Gut intraepithelial T lymphocytes. Curr Opin Immunol 5: 247–252
Haas W, Pereira P, Tonegawa S (1993) Gamma/delta cells. Annu Rev Immunol 11: 637–685
Haury M, Kasahara Y, Schaal S, Bucy RP, Cooper MD (1993) Intestinal T lymphocytes in the chicken express an integrin-like antigen. Eur J Immunol 23: 313–319
Havran WL, Chien Y-H, Allison JP (1991) Recognition of self antigens by skin-derived T cells with invariant yö antigen receptors. Science 252: 1430–1432
Hein WR, Mackay CR (1991) Prominence of γδ T cells in the ruminant immune sγδtem. Immunol Today 12: 30–34
Kasahara Y, Chen CH, Cooper MD (1993) Growth requirements for avian γδ T cells include exogenous cytokines, receptor ligation and in vivo priming. Eur J Immunol 23: 2230–2236
Kaufman J, Salomonsen J (1992) B-G: we know what it is, but what does it do? Immunol Today 13: 1–3
Kaufmann SHE, Blum C, Yamamoto S (1993) Crosstalk between alpha/beta and γδ T cells in vivo: activation of αβ T cell responses after γδ T cell modulation with the monoclonal antibody GL3. Proc Natl Acad Sci USA 90: 9620–9624
Kim HT, Nelson EL, Clayberg C, Sanjanwala M, Sklar J, Krensky AM (1995) γδ T cell recognition of tumor Ig peptide. J Immunol 154: 1614–1623
Knabel M, Cihak J, Lösch U (1993) Characterization of new monoclonal antibodies identifying avian T lymphocyte antigens. lmmunobiology 188: 415–429
Kronenberg M (1994) Antigens recognized by γδ T cells. Curr Opin Immunol 6: 64–71
Lahti JM, Chen CH, Tjoelker LW, Pickel JM, Schat KA, Calnek BW, Thompson CB, Cooper MD (1991) Two distinct αβ T-cell lineages can be distinguished by the differential usage of T-cell receptor Vß gene segments. Proc Natl Acad Sci USA 88: 10956–10960
Lefrancois L, Puddington L (1995) Extrathymic intestinal T-cell development: virtual reality? Immunol Today 16: 16–21
Lillehoj HS (1986) Immune response during coccidiosis in SC and FP chickens. I. In vitro assessment of T cell proliferation response to stage-specific parasite antigens. Vet Immunol Immunopathol 13: 321–330
Lillehoj HS (1987) Effects of immunosuppression on avian coccidiosis: Cyclosporin A but not hormonal bursectomy abrogates host protective immunity. Infect Immun 55: 1616–1621
Lillehoj HS (1989) Intestinal intraepithelial and splenic natural killer cell responses to Eimerian infections in inbred chickens. Infect Immun 57: 1879–84
Lillehoj HS (1990) Cell-mediated immunity in parasitic and bacterial diseases. In: Sharma JM (ed) Avian cellular immunology. CRC Press, Boca Raton, pp 155–182
Lillehoj HS (1994) Analγδis of Eimeria acervulina-induced changes in the intestinal T lymphocyte subpopulations in two chicken strains showing different levels of susceptibility to coccidiosis. Res Vet Sci 56: 1–7
Lillehoj HS, Bacon LD (1991) Increase of intestinal intraepithelial lymphocytes expressing CD8 antigen following challenge infection with Eimeria acervulina. Avian Dis 35: 294–301
Lillehoj HS, Chung KS (1992) Postnatal development of T-lymphocyte subpopulations in the intestinal intraepithelium and lamina propria in chickens. Vet Immunol Immunopathol 31: 347–360
Lynch F, Shevach EM (1992) Activation requirements of newborn thymic γδ T cells. J Immunol 149: 2307–2314
Marmor MD, Benatar T, Ratcliffe MJH (1993) Retroviral transformation in vitro of chicken T cells expressing either cup or γδ T cell receptors by reticuloentheliosis virus strain T. J Exp Med 177: 647–656
Merkle H, Cihak J, Lösch U (1992) The cytotoxic T lymphocyte response in reticuloendotheliosisinfected chickens is mediated by αβ and not by γδ T cells. Immunobiology 186: 292–303
Miller MM, Goto R, Young S, Liu J, Hardy J (1990) Antigens similar to major histocompatibility complex B-G are expressed in the intestinal epithelium in the chicken. Immunogenetics 32: 45–50
Ohteki T, MacDonald HR (1993) Expression of the CD28 costimulatory molecule on subsets of murine intestinal intraepithelial lymphocytes correlates with lineage and responsiveness. Eur J Immunol 23: 1251–1255
Raulet DH (1989) The structure, function, and molecular genetics of the γδT cell receptor. Annu Rev Immunol 7: 175–207
Rocha B, Vassalli P, Guy-Grand D (1992) The extrathymic T-cell development pathway. Immunol Today 13: 449–454
Rust CJ, Verreck F, Vietor H, Koning F (1990) Specific recognition of staphylococcal enterotoxin A by human T cells bearing receptors with the Vy9 region. Nature 346: 572–574
Salomonsen J, Dunon D, Skjodt K, Thorpe D, Vainio O, Kaufman J (1991) Chicken major histocompatibility complex-encoded B-G antigens are found on many cell types that are important for the immune sγδtem. Proc Natl Acad Sci USA 88: 1359–1363
Sano Y, Dudley E, Carding S, Lin RH, Heyday AC, Janeway CA (1993) γδ T cells isolated from intestinal epithelium respond to B-cell lymphoma. Immunology 80: 388–394
Schoel B, Sprenger S, Kaufmann SHE (1994) Phosphate is essential for stimulation of Vy9VS2 thymocytes by mycobacterial low molecular weight ligand. Eur J Immunol 24: 1886–1892
Sharma JM, Prowse SJ, York JJ (1990) Role of cellular immunity in neoplastic and nonneoplastic viral diseases. In: Sharma JM (ed) Avian cellular immunology. CRC Press, Boca Raton, pp 139–154
Sowder JT, Chen CH, Ager LL, Chan MM, Cooper MD (1988) A large subpopulation of avian T cells express a homologue of the mammalian Tγδ receptor. J Exp Med 167: 315–322
Sperling Al, Linsley PS, Barrett TA, Bluestone JA (1993) CD28-mediated costimulation is necessary for the activation of T cell receptor-γδ’ T lymphocytes. J Immunol 151: 6043–6050
Spetz AL, Kourvilsky P, Larsson-Sciard EL (1991) Induction of CD8 molecules on thymic γδ T cells in vitro is dependent upon 041 T cells. Eur J Immunol 21: 2755–2759
Tanaka Y, Sano S, Nieves E, DeLibero G, Resa D, Modlin RL, Brenner MB, Bloom BR, Morita CT (1994) Non-peptide ligands for human γδ T cells. Proc Natl Acad Sci USA 91: 8175–8179
Vainio O, Lassila O (1989) Chicken T cells: differentiation antigens and cell-cell interactions. Poultry Biol 2: 97–102
Vaino O, Riwar B, Brown MH, Lassila O (1991) Characterization of the putative avian CD2 homologue. J Immunol 147: 1593–1599
Viney JL, MacDonald TT (1990) Selective death of T cell receptor γδ intraepithelial lymphocytes by apoptosis. Eur J Immunol 20: 2809–2812
Young JR, Davison TF, Tregaskes CA, Rennie MC, Vainio O (1994) Monomeric homologue of mammalian CD28 is expressed on chicken T cells. J Immunol 152: 3848–3851
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Sanchez-Garcia, F.J., McCormack, W.T. (1996). Chicken γδ T Cells. In: Vainio, O., Imhof, B.A. (eds) Immunology and Developmental Biology of the Chicken. Current Topics in Microbiology and Immunology, vol 212. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80057-3_6
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DOI: https://doi.org/10.1007/978-3-642-80057-3_6
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