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Evidence for Phenotypic Heterogeneity Among B Cells Emigrating from the Bursa of Fabricius: A Reflection of Functional Diversity?

  • E. Paramithiotis
  • M. J. H. Ratcliffe
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 212)

Abstract

The bursa of Fabricius is a primary lymphoid organ with a central role in the establishment of the chicken B cell compartment (for review see Ratcliffe 1989a). The bursa is organized as folds of tissue containing about 104 discrete follicles surrounding a central lumen. Each follicle is divided into an outer cortex and an inner medulla, separated by a complex nucleated cortico-medullary boundary. The bursal lumen is connected by the bursal duct to the large intestine and gut-derived antigens in the chicken rectum can be transported into the bursal lumen (Sovari and Sovari 1977). Indeed, since the terminal portion of the chicken large intestine is capable of reverse peristaltic contractions, this transport can also result in the bursal lumen containing a variety of external antigens.

Keywords

Peripheral Blood Lymphocyte Phenotypic Heterogeneity Medullary Cell Vincristine Sulfate Primary Lymphoid Organ 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bockman DE, Cooper MD (1973) Pinocytosis by epithelium associated with lymphoid follicles in the bursa of Fabricius, appendix and Peyer’s patches. Am J Anat 136: 455–477PubMedCrossRefGoogle Scholar
  2. Ekino S (1993) Role of environmental antigens in B cell proliferation in the bursa of Fabricius at neonatal stage. Eur J Immunol 23: 772–775PubMedCrossRefGoogle Scholar
  3. Ekino S, Matsumo K, Harada S, Fujii H, Nawa Y, Kotani M (1979) Amplification of plaque-forming cells in the spleen after intracloacal antigen stimulation in neonatal chicken. Immunology 37: 811–815PubMedGoogle Scholar
  4. Paramithiotis E, Ratcliffe MJH (1993) Bursa dependent subpopulations of peripheral B lymphocytes in chicken blood. Eur J Immunol 23: 96–102PubMedCrossRefGoogle Scholar
  5. Paramithiotis E, Ratcliffe MJH (1994) B cell emigration directly from the cortex of lymphoid follicles in the bursa of Fabricius. Eur J Immunol 24: 458–463PubMedCrossRefGoogle Scholar
  6. Paramithiotis E, Jacobsen KA, Ratcliffe MJH (1995) Loss of surface immunoglobulin expression precedes B cell death by apoptosis in the bursa of Fabricius. J Exp Med 181: 105–113PubMedCrossRefGoogle Scholar
  7. Pink JRL, Vainio O, Rijnbeek A-M (1985) Clones of B lymphocytes in individual follicles of the bursa of Fabricius. Eur J Immunol 15: 83–87PubMedCrossRefGoogle Scholar
  8. Ratcliffe MJH (1989a) Development of the avian B lymphocyte lineage. CRC Crit Rev Poult Biol 2: 207–234Google Scholar
  9. Ratcliffe MJH (1989b) Generation of immunoglobulin heavy chain diversity subsequent to cell surface immunoglobulin expression in the avian bursa of Fabricius. J Exp Med 170: 1165–1173PubMedCrossRefGoogle Scholar
  10. Reynolds J (1987) Mitotic rate maturation in the Peyer’s patches of fetal sheep and in the bursa of the chick embryo. Eur J Immunol 17: 503–507PubMedCrossRefGoogle Scholar
  11. Sovari R, Sovari TE (1977) Bursa Fabricii as a peripheral lymphoid organ. Transport of various materials from the anal lips to the bursal lymphoid follicles with reference to its immunological importance. Immunology 32: 499–505Google Scholar
  12. Veromaa T, Vainio O, Eerola E, Toivanen P (1988) Monoclonal antibodies against chicken Bu-1 a and Bu-1 b alloantigens. Hybridoma 7: 41–48PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • E. Paramithiotis
    • 1
  • M. J. H. Ratcliffe
    • 2
  1. 1.Division of Developmental and Clinical ImmunologyUniversity of Alabama at Birmingham, 378 Wallace Tumor InstituteBirminghamUSA
  2. 2.Department of Microbiology and ImmunologyMcGill UniversityMontrealCanada

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