Evidence for Phenotypic Heterogeneity Among B Cells Emigrating from the Bursa of Fabricius: A Reflection of Functional Diversity?

  • E. Paramithiotis
  • M. J. H. Ratcliffe
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 212)


The bursa of Fabricius is a primary lymphoid organ with a central role in the establishment of the chicken B cell compartment (for review see Ratcliffe 1989a). The bursa is organized as folds of tissue containing about 104 discrete follicles surrounding a central lumen. Each follicle is divided into an outer cortex and an inner medulla, separated by a complex nucleated cortico-medullary boundary. The bursal lumen is connected by the bursal duct to the large intestine and gut-derived antigens in the chicken rectum can be transported into the bursal lumen (Sovari and Sovari 1977). Indeed, since the terminal portion of the chicken large intestine is capable of reverse peristaltic contractions, this transport can also result in the bursal lumen containing a variety of external antigens.


Peripheral Blood Lymphocyte Phenotypic Heterogeneity Medullary Cell Vincristine Sulfate Primary Lymphoid Organ 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • E. Paramithiotis
    • 1
  • M. J. H. Ratcliffe
    • 2
  1. 1.Division of Developmental and Clinical ImmunologyUniversity of Alabama at Birmingham, 378 Wallace Tumor InstituteBirminghamUSA
  2. 2.Department of Microbiology and ImmunologyMcGill UniversityMontrealCanada

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