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Immunology and Developmental Biology of the Chicken pp 17–28Cite as

Current Concepts in Chicken B Cell Development

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 212))

Abstract

B lymphocytes produce antibody molecules that provide the basis for humoral immune responses. In addition, antibodies in secretions are critical in immune defense. Maternal transmitted antibody plays an important role in immunoprotection of newborns with developing immune systems. An effective humoral immune repertoire has been estimated to require the production of 109 distinct antibody molecules. However, most B cells only produce a single antibody specificity. Thus, an effective immune repertoire requires the maintenance of a vast repertoire of B cells, only a few of which will ever encounter their cognate antigen in any given time period. How such diversity is created during B cell development has been a central question in the field of immunology.

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Authors and Affiliations

  1. Gwen Knapp Center for Lupus and Immunology Research, Howard Hughes Medical Institute, 924 East 57th Street, Chicago, IL, 60637-5420, USA

    P. E. Funk & C. B. Thompson

  2. Departments of Medicine, Molecular Genetics and Cell Biology, and Committee on Immunology, The University of Chicago, Chicago, IL, 60637, USA

    C. B. Thompson

Authors
  1. P. E. Funk
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  2. C. B. Thompson
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Editor information

Editors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstr. 487, 4005, Basel, Switzerland

    Olli Vainio M.D.  & Beat A. Imhof Ph.D.  & 

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© 1996 Springer-Verlag Berlin Heidelberg

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Funk, P.E., Thompson, C.B. (1996). Current Concepts in Chicken B Cell Development. In: Vainio, O., Imhof, B.A. (eds) Immunology and Developmental Biology of the Chicken. Current Topics in Microbiology and Immunology, vol 212. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80057-3_3

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  • DOI: https://doi.org/10.1007/978-3-642-80057-3_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80059-7

  • Online ISBN: 978-3-642-80057-3

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