Abstract
Hematopoiesis is a complex process which involves specification of multiple lineages from a common stem cell and then differentiation and maturation into fully functional blood cells within each lineage. It is clear now that, before reaching the final mature step, cells must first implement a specific morphogenetic program, then express this program to fulfill their physiological functions.
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Beug H, Palmieri S, Freudenstein C, Zentgraf H, Graf T (1982) Hormone-dependent terminal differentiation in vitro of chicken erythroleukemia cells transformed by is mutants of avian erythroblastosis virus. Cell 28: 907–919
Bishop JM (1985) Viral oncogenes. Cell 42: 23–38
Carlberg C, Bendik I, Wyss A, Meier E, Sturzenbecker LJ, Grippo JF, Hunziker W (1993) Two nuclear signalling pathways for vitamin D. Nature 361: 657–660
Damm K, Thompson CC, Evans RM (1989): Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist. Nature 339: 593–597
Dejean A, Bouguelerey L, Grzeschik KH, Tiollais P (1986) Hepatitis B virus DNA integration in a sequence homologous to v-erbA and steroid receptor genes in a hepatocellular carcinoma. Nature 322: 70–72
Desbois C, Aubert D, Legrand C, Pain B, Samarut J (1991) A novel mechanism of action for v-ErbA: abrogation of the inactivation of transcription factor AP-1 by retinoice acid and thyroid hormone receptors. Cell 67: 731–740
Dieterlen-Lièvre F (1988) Birds. In: (eds) Vertebrate blood cells. Rowley AF, Ratcliffe NA, Cambridge University Press, CAmbridge
Disela C, Glineur C, Bugge T, Sap. J, Stengl G, Dodgson J, Stunnenberg H, Beug H, Zenke M (1991) Verb A overexpression is required to extinguish c-erbA function in erythroid cell differentiation and regulation of the erb A target CAII. Genes Dev 5: 2033–2047
Evans RM (1988) The steroid and thyroid hormone receptor family. Sciene 240: 889–895
Forman BM, Samuels HH (1990) Interaction among a subfamily of nuclear receptors: the regulatory zipper mode. Mol Endocrinol 4: 1293–1301
Frykberg L, Palmieri S, Beug H, Graf T, Hayman MJ, Vennström B (1983) Transforming capacities of avian erythroblastosis virus mutants delected in the erbA or erbB oncogenes. Cell 32: 227–238
Gandrillon O, Jurdic P, Benchaibi M, Xiao J-H, Ghysdael J, Samarut J (1987) Expression of the v-erbA oncogene in chicken embryo fibroblasts stimulates their multiplication in vitro and enhances tumor growth in vivo. Cell 49: 687–697
Gandrillon O, Jurdic P, Pain C, Desbois B, Madjar JJ, Moscovici MG, Moscovici C, Samarut J (1989) Expression of v-erbA, an altered nuclear hormone receptor, is sufficient to transform erythrocytic cells in vitro. Cell 58: 115–121
Gandrillon O, Ferrand N, Michaille JJ, Roze L, Zile MH, Samarut J (1994a) CerbAa/T3R and RARs control commitment of hematopoietic self-renewing progenitor cells to apoptosis or differentiation and are antagonized by the v-erbA oncogene. Oncogene 9: 749–758
Gandrillon O, Rascle A, Samarut J (1994b) The v-erbA oncogene: a superb tool for dissecting the involvement of nuclear hormone receptors in differentiation and neoplasia. Int J Oncol 6: 215–231
Garcia M, de Thè H, Tiollais P, Samarut J, Dejean A (1993) A hepatitis B virus preS-retinoic receptor b chimera transforms erythrocytic progenitor cells in vitro. Proc Natl Acad Sci USA 90: 89–93
Gazzola L, Samarut J, Bouabdelli M, Blanchet JP (1980) Early precursors in the erythroid lineage are the specific target cells of the avian erythroblastosis virus in vitro. Cell 22: 683–691
Graf T, Beug H (1983) Role of the v-erbA and v-erbB oncogenes of avian erythroblastosis virus in erythroid cell transformation. Cell 34: 7–9
Graf T, Mc Nagny K, Brady G, Frampton J (1992) Chicken “erythroid” cells transformed by the gag-mybets-encoding E26 leukemia virus are multipotent. Cell 70: 201–213
Green S, Chambon P (1988) Nuclear receptors enhance our understanding of transcriptional regulation. TIG 4: 309–314
Khazaie K, Panayotou G, Aguzzi A, Samarut J, Gazzolo L, Jurdic P (1991) EGF promotes in vivo tumorigenic growth of primary chicken embryo fibroblasts expressing v-myc and enhances in vitro transformation by the v-erbA oncogene. Oncogene 6: 21–28
Leid M, Kastner P, Chambon P (1992) Multiplicity generates diversity in the retinoic acid signalling pathways. TIBS 17: 427–433
Pain B, Melet F, Jurdic F, Samarut J (1990) The carbonic anhydrase II gene, a gene regulated by thyroid hormone and erythropoietin, is repressed by the v-erbA oncogene in erythrocytic cells. New Biol 2: 284–294
Pain B, Woods CM, Saez J, Flickinger T, Raines M, Kaung H-J, Peyrol S, Moscovici C, Moscovici GM, Jurdic P, Lazarides E, Samarut J (1991) EGF-R as a hemopoietic growth factor: the c-erbB product is present in normal chicken erythrocytic progenitor cells and controls their self-renewal. Cell 65: 37–46
Pfahl M (1993) Nuclear receptor/AP-1 interaction. Endocr Rev 14: 651–658
Privalsky ML, Sharif M, Yamamoto KR (1990) The viral erbA oncogene protein, a constitutive repressor in animal cells, is a hormone-regulated activator in yeast. Cell 63: 1277–1286
Rascle A, Ghysdael J, Samarut J (1994) c-ErbA, but not v-ErbA, competes with a putative erythroid repressor for binding to the carbonic anhydrase Il promoter. Oncogene 9: 2853–2867
Samarut J, Bouabdelli M (1980) In vitro development of CFU-E and BFU-E in cultures of embryonic and postembryonic chicken hematopoietic cells. J Cell Physiol 105: 553–563
Samarut J, Gazzolo L (1982) Target cells infected by avian erythroblastosis virus differentiate and become transformed. Cell 28: 921–929
Sap J, Munoz A, Damm K, Goldberg Y, Ghysdael J, Leutz A, Beug H, Vennström B (1986) The c-erbA protein is a high-affinity receptor for thyroid hormone. Nature 324: 635–640
Sap J, Munoz A, Schmitt J, Stunnenberg H, Vennström B (1989) Repression of transcription mediated at thyroid hormone response element by the v-erbA oncogene product. Nature 340: 242–244
Schroeder C, Gibson L, Nordstrom C, Beug H (1993) The estrogen receptor cooperates with the TGFalpha receptor (c-erbB) in regulation of chicken erythroid progenitor self-renewal. EMBO J 12: 951–960
Sharif M, Privalsky ML (1991) VerbA oncogene function in neoplasia correlates with its ability to repress retinoic acid receptor action. Cell 66: 885–893
Weinberger C, Thompson CC, Ong ES, Lebo R, Gruol DJ, Evans RM (1986) The c-erb-A gene encodes a thyroid hormone receptor. Nature 324: 641–646
Yamamoto T, Hihara H, Nishida T, Kawai S, Toyoshima K (1983) A new avian erythroblastosis virus, AEV-H, carries erbB gene responsible for the induction of both erytrhoblastosis and sarcomas. Cell 34: 225–232
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© 1996 Springer-Verlag Berlin Heidelberg
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Samarut, J. (1996). Control of the Differentiation Commitment by Nuclear Hormone Receptors in Chicken Erythrocytic Progenitor Cells. In: Vainio, O., Imhof, B.A. (eds) Immunology and Developmental Biology of the Chicken. Current Topics in Microbiology and Immunology, vol 212. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80057-3_14
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DOI: https://doi.org/10.1007/978-3-642-80057-3_14
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