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Nitric Oxide Involvement in Septic Shock: Do Human Beings behave like Rodents?

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Book cover Yearbook of Intensive Care and Emergency Medicine

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1996))

Abstract

The tremendous interest in the physiological and pathological effects of nitric oxide (NO) is reflected in the enormous number of publications on this subject. Most of the studies investigating the effects of NO were performed in animal models. A Medline search from 1987 to November 1995, revealed that only 8 to 14% of the publications which include the keyword “nitric oxide” also include the keyword “human” (Fig. 1). However, there are several important differences between animal and human observations. The object of this chapter is to review the current knowledge about the role of NO in the hemodynamic alterations of septic shock, and to highlight the differences between animal and human studies.

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  1. J. C. Preiser
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  2. J. L. Vincent
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Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1996 Springer-Verlag Berlin Heidelberg

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Preiser, J.C., Vincent, J.L. (1996). Nitric Oxide Involvement in Septic Shock: Do Human Beings behave like Rodents?. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 1996. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80053-5_31

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  • DOI: https://doi.org/10.1007/978-3-642-80053-5_31

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