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Pressure-Flow Relationships in Liver Vascular Beds during Sepsis

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1996))

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Abstract

Liver failure is considered a critical determinant of mortality in acute respiratory distress/multi-system organ failure/sepsis syndromes [1]. In these pathological processes, liver failure is initiated and propagated by the combination of hepatic hemodynamic abnormalities and cellular dysfunction [2]. Septic patients show a splanchnic hypermetabolic state [3] such that a normal liver blood flow may not be sufficient to support the central role that the liver plays in both preventing systemic sepsis and integrating the responses to surgical and inflammatory stresses. Although maintenance of adequate oxygen and substrate delivery is a critical aspect of the therapeutic strategy during sepsis, detailed hemodynamic studies of the liver circulation, under even normal conditions, are few and raise as many questions as they answer.

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Authors
  1. N. Brienza
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  2. T. Ayuse
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  3. J. L. Robotham
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1996 Springer-Verlag Berlin Heidelberg

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Brienza, N., Ayuse, T., Robotham, J.L. (1996). Pressure-Flow Relationships in Liver Vascular Beds during Sepsis. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 1996. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80053-5_28

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  • DOI: https://doi.org/10.1007/978-3-642-80053-5_28

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-60552-2

  • Online ISBN: 978-3-642-80053-5

  • eBook Packages: Springer Book Archive

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