Prokinetic Use to Facilitate Enteral Feeding

  • P. S. Schoenfeld
  • D. K. Heyland
  • D. J. Cook
Conference paper
Part of the Yearbook of Intensive Care and Emergency Medicine book series (YEARBOOK, volume 1996)

Abstract

Critical illness is characterized by multiple factors which can alter the function and structure of the gastrointestinal (GI) tract. These alterations may include changes in gastric blood flow, mucosal injury, disturbance of gut immune function and GI motility. The clinical conditions predisposing patients to these GI problems include, but are not limited to, overwhelming infection, tissue hypoxia, starvation, and use of opiates, benzodiazepines and paralytic agents [1]. Early enteral feeding, facilitated by the use of prokinetic agents, may lessen the impact of these insults on the GI tract.

Keywords

Placebo Warfarin Acetylcholine Theophylline Erythromycin 

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References

  1. 1.
    Beal AL, Cerra FB (1994) Multiple organ failure in the 1990’s: Systemic inflammatory response and organ dysfunction. JAMA 271: 226–233PubMedCrossRefGoogle Scholar
  2. 2.
    Alverdy J, Chi HS, Sheldon G (1985) The effect of parenteral nutrition on gastrointestinal immunity: The importance of enteral immunity. Ann Surg 202: 681–684PubMedCrossRefGoogle Scholar
  3. 3.
    Alverdy JC, Aoys E, Moss GS (1988) TPN promotes bacterial translocation from the gut. Surgery 104: 185–190PubMedGoogle Scholar
  4. 4.
    Saito H, Trocki O, Alexander JW, Kopcha R, Heyd T, Joffe SN (1987) Effect of route of administration on the nutritional state, catabolic hormone secretion and gut mucosal integrity after burn injury. JPEN 11: 1–7CrossRefGoogle Scholar
  5. 5.
    Zaloga GP, Bortenschlager L, Black KW, Prielipp R (1992) Immediate postoperative enteral feeding decreases weight loss and improves healing after abdominal surgery in rats. Crit Care Med 20: 115PubMedCrossRefGoogle Scholar
  6. 6.
    Roberts P, Black K, Zaloga G (1993) Enteral nutrition improves survival and prevents bacterial dissemination following methotrexate. Crit Care Med 21 (Suppl): S287 (Abst)CrossRefGoogle Scholar
  7. 7.
    Kudsk KA, Stone JM, Carpenter G, Sheldon GF (1983) Enteral and parenteral feeding influences mortality after hemoglobin- E. coli peritonitis in normal rats. J Trauma 23: 605–609PubMedCrossRefGoogle Scholar
  8. 8.
    Zaloga GP, Knowles R, Black KW, Prielipp R (1990) Total parenteral nutrition increases mortality after hemorrhage. Crit Care Med 19: 54–59CrossRefGoogle Scholar
  9. 9.
    Schroeder D, Gillanders L, Mahr K, Hill GL (1991) Effects of immediate postoperative enteral nutrition on body composition, muscle function, and wound healing. JPEN 15: 376–383CrossRefGoogle Scholar
  10. 10.
    Moore FA, Feliciano DV, Andrassy RJ, et al (1992) Early enteral feeding, compared with parenteral, reduces septic complications. The results of a Meta-analysis. Ann Surg 216: 172–183PubMedCrossRefGoogle Scholar
  11. 11.
    Heyland DK, Cook DJ, Guyatt GH (1993) Enteral nutrition: A critical appraisal of the evidence. Int Care Med 19: 435–442CrossRefGoogle Scholar
  12. 12.
    Heyland D, Cook DJ, Winder B, Brylowski L, Van de Mark H, Guyatt G (1995) Early, intragastric enteral nutrition in the critically ill patient: A prospective survey. Crit Care Med 23: 1055–1060PubMedCrossRefGoogle Scholar
  13. 13.
    Heyland DK, Cook DJ, Winder B, Guyatt GH (1996) How well do critically ill patients tolerate early, intragastric enteral nutrition. Clin Intensive Care (In Press)Google Scholar
  14. 14.
    Ott L, Young B, Phillips R, et al (1991) Altered gastric emptying in the head-injured patient: Relationship to feeding intolerance. J Neurosurg 74: 738–742PubMedCrossRefGoogle Scholar
  15. 15.
    Dive A, Moulart M, Jonard P, Jamart J, Mahieu P (1994) Gastroduodenal motility in mechanically ventilated critically ill patients: A manometric study. Crit Care Med 22: 441–447PubMedCrossRefGoogle Scholar
  16. 16.
    Heyland D, Cook DJ (1994) The effect of narcotics on gastric emptying in the critically ill patients. Am J Respir Crit Care Med 149: A939 (Abst)Google Scholar
  17. 17.
    Renolds JC (1989) Prokinetic agents: A key in the future of gastroenterology. Gastro Clin N Am 18: 437–457Google Scholar
  18. 18.
    Harrington PR, Hamilton CW, Brogden RN, et al (1983) Metoclopramide: An updated review of its pharmacologic properties and clinical use. Drugs 25: 451–454PubMedCrossRefGoogle Scholar
  19. 19.
    Brogden RN, Carmine AA, Heel RC, et al (1982) Domperidone: A review of its pharmacological activity, pharmacokinetics and therapeutic efficacy in the symptomatic treatment of chronic dyspepsia and as an antiemetic. Drugs 24: 1080–1082Google Scholar
  20. 20.
    Schuurkes A, Van Nueten JM, Van Daele PGH, Reyntjens AJ, Janssen PAJ (1985) Motorstimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig. J Pharm Exp Ther 234: 775–783Google Scholar
  21. 21.
    Taniyama K, Nakayama S, Takeda K, et al (1991) Cisapride stimulates motility of the intestine via the 5-Hydroxytryptamine receptors. J Pharm Exp Ther 258: 1098–1104Google Scholar
  22. 22.
    Reyntjens A, Verlinden M, De Coster R, et al (1984) Clinical pharmacological evidence for cisapride’s lack of antodopaminergic or direct cholinergic properties. Curr Ther Res 36: 1045–1052Google Scholar
  23. 23.
    Hardcastle J, Hardcastle PT, Kelleher DK (1984) The action of R 51619 on transport processes in the rat small intestine. J Pharm Pharmacol 36: 139–140PubMedCrossRefGoogle Scholar
  24. 24.
    van der Waaij D, Berghuis-de Vries JM, Lekkerkerk-van der Wees JEC (1971) Colonization resistance of the digestive tract in conventional and antibiotic-treated mice. J Hyg Camb 69: 405–409PubMedCrossRefGoogle Scholar
  25. 25.
    Janssens J, Peeter TL, Vantrappen G, et al (1990) Improvement of gastric emptying in diabetic gastroparesis by erythromycin. New Engl J Med 322: 1028–1031PubMedCrossRefGoogle Scholar
  26. 26.
    Feldman M, Smith HJ (1987) Effects of cisapride on gastric emptying of indigestible solids in patients with gastroparesis diabeticorum. Gastroenterology 92: 171–174PubMedGoogle Scholar
  27. 27.
    Yeo CJ, Barry MK, Sauter PK, et al (1993) Erythromycin accelerates gastric emptying after pancreaticoduodenectomy. A prospective, randomized, placebo-controlled trial. Ann Surg 218: 229–238PubMedCrossRefGoogle Scholar
  28. 28.
    Davidson ED, Hersh T, Brinner RA, Barnett SM, Boyle LP (1979) The effects of metoclopramide in post-operative ileus. A randomized, double-blind study. Ann Surg 190: 27–30PubMedCrossRefGoogle Scholar
  29. 29.
    Van Rooy F, Creve U, Verlinden M, Hubens A (1988) Effect of cisapride on the postcholecystectomy upper gastrointestinal transit time. Int J Clin Pharm Ther Tox 26: 263–268Google Scholar
  30. 30.
    Boghaert A, Haesaert G, Mourisse P, Verlinden M (1987) Placebo-controlled trial of cisapride in postoperative ileus. Acta Anaesth Belg 38: 195–199PubMedGoogle Scholar
  31. 31.
    Von Ritter C, Hunter S, Hinder RA (1987) Cisapride does not reduce postoperative paralytic ileus. S Afr J Surg 25: 19–21Google Scholar
  32. 32.
    Benson MJ, Roberts JP, Wingate DL, et al (1994) Small bowel motility following major intra-abdominal surgery: The effects of opiates and rectal cisapride. Gastroenterology 106: 924–936PubMedGoogle Scholar
  33. 33.
    Roberts JP, Benson MJ, Rogers J, Deeks JJ, Wingate DL, Williams NS (1995) Effect of cisapride on colonic motility in the early postoperative period following left colonic anastomosis. Dis Colon Rectum 38: 139–145PubMedCrossRefGoogle Scholar
  34. 34.
    Rowbotham DJ, Nimmo WS (1987) Effect of cisapride on morphine-induced delay in gastric emptying. Br J Anaesth 59: 536–539PubMedCrossRefGoogle Scholar
  35. 35.
    Spapen H, Duinslaeger L, Diltoer M, Gillet R, Bossuyt A, Huyghens (1994) Gastric emptying in critically ill intensive care patients is accelerated by adding cisapride to a standard enteral feeding protocol. Crit Care Med 22: 208a (Abst)CrossRefGoogle Scholar
  36. 36.
    Dive A, Miesse C, Galanti L, et al (1995) Effect of erythromycin on gastric motility in mechanically ventilated patients: A double-blind, randomized, placebo-controlled study. Crit Care Med 23: 1356–1362PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • P. S. Schoenfeld
  • D. K. Heyland
  • D. J. Cook

There are no affiliations available

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