Abstract
In 1985, an article by Beutler et al. [1] demonstrated for the first time that a therapy directed against tumor necrosis factor (TNF) was protective in a septic shock model. In this study, the earlier an anti-TNF antiserum was given, the higher the survival rates in endotoxin-challenged mice. This led to an explosion in the scientific literature of investigations demonstrating that inhibition of various inflammatory mediators was protective in animals receiving microbial challenges. Likewise, dozens of published studies showed that various host inflammatory mediators, when given to animals, reproduced most of the manifestations of microbial challenge.
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References
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© 1996 Springer-Verlag Berlin Heidelberg
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Eichacker, P.Q., Natanson, C. (1996). Rethinking the Anti-Inflammatory Approach to Septic Shock. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 1996. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80053-5_15
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DOI: https://doi.org/10.1007/978-3-642-80053-5_15
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