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Yearbook of Intensive Care and Emergency Medicine pp 105–110Cite as

Interleukin-10 Production during Septic Shock

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Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1996))

Abstract

Human interleukin (IL)-10 is a protein of 160 amino acids (molecular weight: 18.5 kDa) containing two intramolecular disulfide bonds [1, 2]. It is acid-labile and appears in soluble form as a homodimer. The gene encoding IL-10, which is located on chromosome 1 both in mouse and man, contains several noncoding sequences which are thought to control its transcription and the stability of the corresponding mRNA [3]. Several cell types can produce IL-10 including CD4+ and CD8+ T cells, macrophages/monocytes, B cells, keratinocytes, mesangial cells and a variety of tumor cells [1]. In most inflammatory disorders including septic shock, cells of the monocytic lineage represent the major source of IL-10.

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Authors
  1. M. Goldman
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  2. A. Marchant
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1996 Springer-Verlag Berlin Heidelberg

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Goldman, M., Marchant, A. (1996). Interleukin-10 Production during Septic Shock. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 1996. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80053-5_10

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  • DOI: https://doi.org/10.1007/978-3-642-80053-5_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-60552-2

  • Online ISBN: 978-3-642-80053-5

  • eBook Packages: Springer Book Archive

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