Abstract
The assumption of HWE is essential to estimate the genotype frequencies, particularly in systems with a large number of alleles, as it is the case of VNTR loci. HWE can be checked by comparing the observed and expected number of homocygotes and heterozygotes. Some authors claim that VNTR loci show an excess of homocygotes due mainly to population heterogeneity (Lander, 1989), that is, the existence of two or more groups within the population whose individuals show limited intergroup mating and different allele frequencies (Devlin et al., 1990).
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Alonso, S., Castro, A., Fernández-Fernández, I., García-Orad, A., Tamayo, G., Martínez de Pancorbo, M. (1996). Null Alleles Detection in Loci D1S7, D7S21 and D12S11 by PCR. In: Carracedo, A., Brinkmann, B., Bär, W. (eds) 16th Congress of the International Society for Forensic Haemogenetics (Internationale Gesellschaft für forensische Hämogenetik e.V.), Santiago de Compostela, 12–16 September 1995. Advances in Forensic Haemogenetics, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80029-0_41
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DOI: https://doi.org/10.1007/978-3-642-80029-0_41
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