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Analysis of D1S80 VNTR Allele Polymorphism and Association with a Nearby Flanking Sequence Polymorphism in Two Spanish Populations

  • C. Albarrán
  • O. García
  • R. Deka
  • A. Alonso
  • P. Martín
  • M. Sancho
  • D. N. Stivers
  • R. Chakraborty
Conference paper
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 6)

Abstract

Variable number of tandem repeats (VNTR) loci are highly informative markers for linkage analysis and identity testing. In addition to the variation in the number of repeats, some VNTR loci display variabilty of the repeat sequence so that an additional polymorphism level can be observed analyzing the interspersion pattern of variant repeats along the tandem repeat array (Jeffreys et al. 1991; Neil and Jeffreys 1993). For the majority of VNTR loci, however, the extent of polymorphism of the flanking sequences is not known, despite some early studies showing linkage between VNTR specific-alleles and nearby RFLPs (Higgs et al. 1986; Cox et al. 1988; Renges et al. 1992; Martinson et al. 1994).

Keywords

Haplotype Frequency Spanish Population Basque Country Tandem Repeat Array Interspersion Pattern 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • C. Albarrán
    • 1
  • O. García
    • 2
  • R. Deka
    • 3
  • A. Alonso
    • 1
  • P. Martín
    • 1
  • M. Sancho
    • 1
  • D. N. Stivers
    • 4
  • R. Chakraborty
    • 4
  1. 1.Sección de Biología.Instituto de ToxicologíaMadridSpain
  2. 2.Laboratorio UTAP. Departamento de InteriorGobierno VascoBilbaoSpain
  3. 3.Department of Human GeneticsUniversity of PittsburghPittsburghUSA
  4. 4.Human Genetics Center, Health Science CenterUniversity of TexasHoustonUSA

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