Analysis of the Short Tandem Repeat Polymorphism D18S51: Allele Frequencies and Sequence Studies

  • P. Berschick
  • J. Reinhold
Conference paper
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 6)


The analysis of Short Tandem Repeat polymorphisms is widely used as a method for human identification. There is a demand to combine several STR loci with high discrimination power for multiplex analysis. STR polymorphisms with few alleles (e.g.: TC11, F13A) do not have the discrimination power compared to STR-systems like SE33 (ACTBP2). SE33 has more than 30 alleles and thus the space for the combination with other STR loci in multiplex analysis is reduced. Therefore STR polymorphisms like FGA (HUMFIBRA) and D18S51 with about 15–20 alleles seem to be a good compromise.


Short Tandem Repeat Short Tandem Repeat Locus Multiplex Analysis Allele Length GAAA Repeat 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Berschick P, Henke J, Henke L (1995) Analysis of the Short Tandem Repeat polymorphism SE33: A new high resolution separation of SE33 by means of direct blotting electrophoresis. In: Bär W, Fiori A, Rossi U (eds) Advances in Forensic Haemogenetics 5, Springer, Berlion Heidelberg, New York, p 323–325Google Scholar
  2. Clark JM (1988) Novel non-template addition reactions catalyzed by procaryotic and eucaryotic DNA polymerases. NAR 16, 9677–9686.PubMedCrossRefGoogle Scholar
  3. Kimpton CP, Gill P, Walton A, Urquhart A, Millican ES, Adams M (1993) Automated DNA profiling employing multiplex amplification of short tandem repeat loci. PCR Methods Appl. 3, 13–22.PubMedGoogle Scholar
  4. Straub RE, Speer MC, Luo Y, Rojas K, Overhauser J, Ott J Gilliam C (1993) A microsatellite genetic linkage map of human chromosome 18. Genomics 15, 48–56.PubMedCrossRefGoogle Scholar
  5. Urquhart A, Oldroyd NJ, Kimpton CP, Gill P (1995) Highly discriminating heptaplex short tandem repeat PCR system for forensic identification. BioTechniques 18, 116–121.PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • P. Berschick
    • 1
  • J. Reinhold
    • 1
    • 2
  1. 1.Institut fuer ZoophysiologieDuesseldorfGermany
  2. 2.Institut fuer LabormedizinWuerzburgGermany

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