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Detection of a Silent GC Allele in a Danish Mother and Child

  • M. Thymann
  • H. E. Hansen
  • J. Dissing
Conference paper
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 6)

Abstract

The Group-Specific Component (GC, vitamin-D binding protein, DBP) is a polymorphic plasmaprotein still used for paternity investigations in many laboratories (theoretical chance of exclusion 31%). In a Danish case of disputed paternity inverse homozygosity was observed in a mother and her child by isoelectric focusing. Extended investigations including conventional bloodtyping systems, RFLP- and AMP/FLP-examinations were carried out. PCR/SSCP analysis of a DNA fragment containing two mutation sites specific for the alleles GC 1F, GC 1S and GC 2 in exon 11 of the GC gene was also performed.

Keywords

Amplify Fragment Length Polymorphism Paternity Testing Amplify Fragment Length Polymorphism Technique Danish Case Major Deletion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • M. Thymann
    • 1
  • H. E. Hansen
    • 1
  • J. Dissing
    • 1
  1. 1.Department of Forensic Genetics, Institute of Forensic MedicineUniversity of CopenhagenCopenhagenDenmark

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