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A Study of Polymorphism of Antithrombin III at the Level of Both Protein and DNA in a Chinese Population

  • Conference paper
16th Congress of the International Society for Forensic Haemogenetics (Internationale Gesellschaft für forensische Hämogenetik e.V.), Santiago de Compostela, 12–16 September 1995

Part of the book series: Advances in Forensic Haemogenetics ((HAEMOGENETICS,volume 6))

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Abstract

A systematical study of structure and genomic organization of antithrombin III (ATIII) (Lane and Caso, 1989) indicated that there are two polymorphisms: an intragenic polymorphism arising from a translationally silent A to G transition in condon 305, and a length polymorphism arising from the presence of 32 BP or 108 BP non-homologous sequences 345bp upstream from the translation intiation condon. Products of three ATIII codominant autosomal alleles have been revealed by IEF from Caucasoid and Negroid (Kambol and Ferrell, 1988). On the other hand, the fragment length polymorphism of ATIII has been studied by Southern blotting (Bock and Levitan, 1983) and by PCR (Scino, 1989) in Caucasian population.The purpose of this study is to reveal the genetic polymorphism of ATIII in a Chinese population at the level of both protein and DNA and to explore the relationship between these two kinds of polymorphisms.

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Author information

Authors and Affiliations

  1. Graduate Genetics Program, The George Washington University, Washington DC, 20052, USA

    Qing Gou

  2. Department of Forensic Biology, West China University of Medical Sciences, Chengdu, 610044, PR China

    Yiping Hou, Youfang Zhang & Meiyun Wu

Authors
  1. Qing Gou
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  2. Yiping Hou
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  3. Youfang Zhang
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  4. Meiyun Wu
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Editor information

Editors and Affiliations

  1. Institute of Legal Medicine, University of Santiago de Compostela, c/San Francisco s/n, E-15705, Santiago de Compostela, Spain

    Angel Carracedo

  2. Institut für Rechtsmedizin, Universität Münster, Von-Esmarch-Straße 86, D-48149, Münster, Germany

    Bernd Brinkmann

  3. Institute for Legal Medicine, University of Zurich, Winterthurerstraße 190, CH-8057, Zurich, Switzerland

    Walter Bär

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© 1996 Springer-Verlag Berlin Heidelberg

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Gou, Q., Hou, Y., Zhang, Y., Wu, M. (1996). A Study of Polymorphism of Antithrombin III at the Level of Both Protein and DNA in a Chinese Population. In: Carracedo, A., Brinkmann, B., Bär, W. (eds) 16th Congress of the International Society for Forensic Haemogenetics (Internationale Gesellschaft für forensische Hämogenetik e.V.), Santiago de Compostela, 12–16 September 1995. Advances in Forensic Haemogenetics, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80029-0_124

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  • DOI: https://doi.org/10.1007/978-3-642-80029-0_124

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-60492-1

  • Online ISBN: 978-3-642-80029-0

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