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A Study of Polymorphism of Antithrombin III at the Level of Both Protein and DNA in a Chinese Population

  • Qing Gou
  • Yiping Hou
  • Youfang Zhang
  • Meiyun Wu
Conference paper
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 6)

Abstract

A systematical study of structure and genomic organization of antithrombin III (ATIII) (Lane and Caso, 1989) indicated that there are two polymorphisms: an intragenic polymorphism arising from a translationally silent A to G transition in condon 305, and a length polymorphism arising from the presence of 32 BP or 108 BP non-homologous sequences 345bp upstream from the translation intiation condon. Products of three ATIII codominant autosomal alleles have been revealed by IEF from Caucasoid and Negroid (Kambol and Ferrell, 1988). On the other hand, the fragment length polymorphism of ATIII has been studied by Southern blotting (Bock and Levitan, 1983) and by PCR (Scino, 1989) in Caucasian population.The purpose of this study is to reveal the genetic polymorphism of ATIII in a Chinese population at the level of both protein and DNA and to explore the relationship between these two kinds of polymorphisms.

Keywords

Chinese Population Genetic Linkage Analysis Linkage Disequilibrium Coefficient Chelex100 Method Intragenic Polymorphism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Qing Gou
    • 1
  • Yiping Hou
    • 2
  • Youfang Zhang
    • 2
  • Meiyun Wu
    • 2
  1. 1.Graduate Genetics ProgramThe George Washington UniversityUSA
  2. 2.Department of Forensic BiologyWest China University of Medical SciencesChengduPR China

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