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Analysis of sequence variations in the alleles from three STR loci.

  • Conference paper
16th Congress of the International Society for Forensic Haemogenetics (Internationale Gesellschaft für forensische Hämogenetik e.V.), Santiago de Compostela, 12–16 September 1995

Part of the book series: Advances in Forensic Haemogenetics ((HAEMOGENETICS,volume 6))

Abstract

DNA polymorphic loci resulting from variations in the number of short tandem repeats (STR), especially tetranucleotide repeats, are finding increased application in human identification. The main advantage of these loci are the small size of their alleles and their ability to be detected by PCR based DNA amplification. We have developed a multiplex system composed of 3 loci. The alleles from each locus fall within discreet size ranges and do not overlap. Although in theory the alleles from these loci differ by changes in the number of tetranucleotide repeats, additional variants may exist due to sequence variations between similar size alleles. Sequence studies, by Adams et al. (1993), of the alleles of the locus D11S554 have shown the occurrence of sequence variants among the same size alleles. The objective of this study was to report our initial findings on the primary sequence of multiple alleles from the 3 polymorphic STR loci.

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References

  • Adams M, Urquhart A, Kimpton C, Gill P (1993) The human D11S554 locus: four distinct families of repeat pattern alleles at one locus. Human Molecular Genetics 2:1373–1376

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  • Neuweiler J, Perlee L, Venturini J, Balazs I (1995) Properties of an STR multiplex marker system suitable for paternity and forensic determinations, this proceeding.

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Author information

Authors and Affiliations

  1. Lifecodes Corp., 550 West Ave., Stamford, Ct, 06902, USA

    L. Perlee, J. Neuweiler & I. Balazs

Authors
  1. L. Perlee
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  2. J. Neuweiler
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  3. I. Balazs
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Editor information

Editors and Affiliations

  1. Institute of Legal Medicine, University of Santiago de Compostela, c/San Francisco s/n, E-15705, Santiago de Compostela, Spain

    Angel Carracedo

  2. Institut für Rechtsmedizin, Universität Münster, Von-Esmarch-Straße 86, D-48149, Münster, Germany

    Bernd Brinkmann

  3. Institute for Legal Medicine, University of Zurich, Winterthurerstraße 190, CH-8057, Zurich, Switzerland

    Walter Bär

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© 1996 Springer-Verlag Berlin Heidelberg

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Perlee, L., Neuweiler, J., Balazs, I. (1996). Analysis of sequence variations in the alleles from three STR loci.. In: Carracedo, A., Brinkmann, B., Bär, W. (eds) 16th Congress of the International Society for Forensic Haemogenetics (Internationale Gesellschaft für forensische Hämogenetik e.V.), Santiago de Compostela, 12–16 September 1995. Advances in Forensic Haemogenetics, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80029-0_12

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  • DOI: https://doi.org/10.1007/978-3-642-80029-0_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-60492-1

  • Online ISBN: 978-3-642-80029-0

  • eBook Packages: Springer Book Archive

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