Novel Polymorphisms in the Coding Sequence of the Coagulation Factor XIII A-Subunit and their Haplotype Diversity
Genetic polymorphism of coagulation factor XIII A-subunit (F13A) is defined by four suballeles, F13A*1A, *1B, *2A, and *2B (Suzuki 1988). Some of the authors have recently determined nucleotide substitutions responsible for the allelic differences of the F13A protein by using the polymerase chain reaction (PCR) and direct sequencing, and have reported PCR-mediated typing procedure for the four alleles (Suzuki 1994). Further analysis of the coding sequences of the F13A gene has demonstrated several novel polymorphisms based on nucleotide substitutions in the coding sequences. Here, we present these nucleotide site polymorphisms and haplotypic combinations of them.
KeywordsNucleotide Change Allelic Difference Single Strand Conformational Polymorphism Intragenic Recombination Haplotypic Combination
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