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Novel Polymorphisms in the Coding Sequence of the Coagulation Factor XIII A-Subunit and their Haplotype Diversity

  • Koichi Suzuki
  • Misa Iwata
  • Tatsushige Fukunaga
  • Goichi Ishimoto
  • Jürgen Henke
  • Lotte Henke
  • Maria Szekelyi
  • Shigenori Ito
  • Hiroko Tsuji
  • Akiyoshi Tamura
Conference paper
Part of the Advances in Forensic Haemogenetics book series (HAEMOGENETICS, volume 6)

Abstract

Genetic polymorphism of coagulation factor XIII A-subunit (F13A) is defined by four suballeles, F13A*1A, *1B, *2A, and *2B (Suzuki 1988). Some of the authors have recently determined nucleotide substitutions responsible for the allelic differences of the F13A protein by using the polymerase chain reaction (PCR) and direct sequencing, and have reported PCR-mediated typing procedure for the four alleles (Suzuki 1994). Further analysis of the coding sequences of the F13A gene has demonstrated several novel polymorphisms based on nucleotide substitutions in the coding sequences. Here, we present these nucleotide site polymorphisms and haplotypic combinations of them.

Keywords

Nucleotide Change Allelic Difference Single Strand Conformational Polymorphism Intragenic Recombination Haplotypic Combination 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Koichi Suzuki
    • 1
  • Misa Iwata
    • 1
  • Tatsushige Fukunaga
    • 2
  • Goichi Ishimoto
    • 2
  • Jürgen Henke
    • 3
  • Lotte Henke
    • 4
  • Maria Szekelyi
    • 3
  • Shigenori Ito
    • 1
  • Hiroko Tsuji
    • 1
  • Akiyoshi Tamura
    • 1
  1. 1.Department of Legal MedicineOsaka Medical CollegeTakatuski 569Japan
  2. 2.Department of Legal MedicineMie University School of MedicineTsu 514Japan
  3. 3.Institut für BlutgruppenforschungKölnGermany
  4. 4.Abtl. forensische Blutgruppenkunde und MolekulargenetikInstitut für BlutgruppenforschungDüsseldorfGermany

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