A History of Direct Current Measurement as it Relates to Tissue Proliferation
One of the central tenets of evolutionary biology is the conservation of morphological and behavioural characteristics in response to environmental demands. When challenged by the demands of a changing ecosystem, organisms typically adapt by successive modifications of existing biological machinery rather than the development of entirely new systems. A case in point involves the use of metabolic machinery which is responsible for the gradient maintained between a cell’s internal and external environment. All differentiated cells actively maintain a selective ionic gradient across the cell membrane. When these cells are aggregated at the tissue level, a combination of epithelial cell-to- cell cohesion and polarity in the distribution of ionic pumps create and maintain appropriate internal salt and fluid levels within the tissue with respect to the external environment.
KeywordsCell Cohesion Direct Current Measurement Surface Electrical Potential Internal Salt Neural Crest Formation
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