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Higher Efficiency of 131I-Labeled Anti-Carcinoembryonic Antigen—Monoclonal Antibody F(ab′)2 as Compared to Intact Antibodies in Radioimmunotherapy of Established Human Colon Carcinoma Grafted in Nude Mice

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Systemic Radiotherapy with Monoclonal Antibodies

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 141))

Abstract

Radioimmunotherapy using 131I-labeled antibodies has been shown to be very efficient in patients with B cell lymphoma: 85% of patients responded with complete remission upon myeloablative therapy using radiolabeled MB-1 and B1 antibody (Press et al. 1993). In treatment of solid tumors, however, such response rates have not been reached (Mach et al. 1991; Goldenberg and Schlom 1993; Breitz et al. 1992).

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Author information

Authors and Affiliations

  1. Division of Nuclear Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

    F. Buchegger, B. Delaloye & A. Bischof-Delaloye

  2. Institute of Biochemistry, School of Medicine, University of Lausanne, Ch. des Boveresses 155, 1066, Epalinger, Switzerland

    J.-P. Mach, S. Folli & A. Pèlegrin

  3. Swiss Institute for Experimental Cancer Research, Switzerland

    J.-P. Mach

Authors
  1. F. Buchegger
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  2. J.-P. Mach
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  3. S. Folli
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  4. B. Delaloye
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  5. A. Bischof-Delaloye
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  6. A. Pèlegrin
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Editor information

Editors and Affiliations

  1. Klinik für Strahlentherapie, Städt. Kliniken Karlsruhe, Moltkestraße 14–16, 76133, Karlsruhe, Germany

    Marie-Luise Sautter-Bihl (Ärztliche Direcktorin) (Ärztliche Direcktorin)

  2. Klinik für Nuklearmedizin, Katharinenhospital Stuttgart, Kriegsbergstr. 60, 70174, Stuttgart, Germany

    Heiner Bihl

  3. Radiologische Klinik Abteilung für Klinische Radiologie, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany

    Michael Wannenmacher

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© 1996 Springer-Verlag Berlin · Heidelberg

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Buchegger, F., Mach, JP., Folli, S., Delaloye, B., Bischof-Delaloye, A., Pèlegrin, A. (1996). Higher Efficiency of 131I-Labeled Anti-Carcinoembryonic Antigen—Monoclonal Antibody F(ab′)2 as Compared to Intact Antibodies in Radioimmunotherapy of Established Human Colon Carcinoma Grafted in Nude Mice. In: Sautter-Bihl, ML., Bihl, H., Wannenmacher, M. (eds) Systemic Radiotherapy with Monoclonal Antibodies. Recent Results in Cancer Research, vol 141. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79952-5_3

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  • DOI: https://doi.org/10.1007/978-3-642-79952-5_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79954-9

  • Online ISBN: 978-3-642-79952-5

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