Abstract
Use of radiolabeled monoclonal antibodies for diagnosis of malignancy has been under investigation for a number of years with variable success. The natural outgrowth of these investigations has been attempts to use radiolabeled antibodies for therapy. Development of radioimmunotherapy clinical trials has also been slow in all aspects of malignancy. However, the best results have been achieved in hematologic malignancies (Press et al. 1993; Kaminski et al. 1990). The highest response rates have been observed in those studies using antibodies directed against malignant non-Hodgkin’s lymphoma. Our use of radiolabeled antibodies in lymphoma treatment is described in this article, with emphasis on high-dose protocols.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Eary JF, Appelbaum FR, Durack LD, Brown P (1989) Preliminary validation of the opposing view method for quantitative gamma camera imaging. Med Phys 16 (3): 382–387
Eary J, Press O, Badger C, Durack L, Richter K, Addison S, Krohn K, Fisher D, Porter B, Williams D, Martin P, Appelbaum F, Levy R, Brown S, Miller R, Nelp W, Bernstein I (1990) Imaging and treatment of B-cell lymphoma. J Nucl Med 31: 1257–1268
Kaminski M, Fig L, Del Rosario R, Miller R, Buchsbaum D, Mudgett E, Wahl R (1990) Radioimmunotherapy of advanced B-cell lymphoma with non bone marrow ablative doses of 131I MB-1 antibody. Antibody Immunoconj Radiopharm 3 (1): 58
Press OW, DeSantes K, Anderson SK, Geissler F (1990) Inhibition of catabolism of radiolabeled antibodies by tumor cells using lysosomotropic amine and carboxylic ionophores. Cancer Res 50: 1243–1250
Press O, Eary J, Appelbaum F, Martin P, Badger C, Nelp W, Glen S, Butchko G, Fisher D, Porter B, Matthews D, Fisher L, Bernstein I (1993) Radiolabeled antibody therapy of B-cell lymphomas with autologous bone marrow support. N Engl J Med 329 (17): 1219–1224
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer-Verlag Berlin · Heidelberg
About this paper
Cite this paper
Eary, J.F., Press, O.W. (1996). High Dose Radioimmunotherapy in Malignant Lymphoma. In: Sautter-Bihl, ML., Bihl, H., Wannenmacher, M. (eds) Systemic Radiotherapy with Monoclonal Antibodies. Recent Results in Cancer Research, vol 141. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79952-5_12
Download citation
DOI: https://doi.org/10.1007/978-3-642-79952-5_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-79954-9
Online ISBN: 978-3-642-79952-5
eBook Packages: Springer Book Archive