Nitric Oxide as a Mediator in Gram-Positive Sepsis

  • J. Wilkinson
  • S. Sriskandan
  • J. Cohen
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 24)


Sepsis and its sequelae are a cause of significant morbidity and mortality worldwide [1], due in part to a rise in the incidence of nosocomial infections as a consequence of the increased use of invasive procedures. Septic shock is now the commonest cause of death on intensive care units (ICU) in the US [2]. Traditionally, septic shock has been attributed to gram-negative infections, but it may be caused by gram-positive bacteria and other organisms. Gram-positive bacteria are increasingly being recognized as the cause of septic shock and sepsis syndromes [3]; in most series, they account for 40–50% of cases of bacteremia, and the mortality is at least as high as that seen complicating gram-negative infections.


Nitric Oxide Septic Shock Necrotizing Fasciitis Adult Respiratory Distress Syndrome Toxic Shock Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • J. Wilkinson
  • S. Sriskandan
  • J. Cohen

There are no affiliations available

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