Nitric Oxide as a Mediator in Gram-Positive Sepsis
Sepsis and its sequelae are a cause of significant morbidity and mortality worldwide , due in part to a rise in the incidence of nosocomial infections as a consequence of the increased use of invasive procedures. Septic shock is now the commonest cause of death on intensive care units (ICU) in the US . Traditionally, septic shock has been attributed to gram-negative infections, but it may be caused by gram-positive bacteria and other organisms. Gram-positive bacteria are increasingly being recognized as the cause of septic shock and sepsis syndromes ; in most series, they account for 40–50% of cases of bacteremia, and the mortality is at least as high as that seen complicating gram-negative infections.
KeywordsPolysaccharide Penicillin Nitrite Interferon Histamine
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