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Nitric Oxide as a Mediator of Hypotension and Inflammation in Sepsis

  • Chapter
Role of Nitric Oxide in Sepsis and ADRS

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 24))

  • 57 Accesses

Abstract

Septic shock is a severe systemic inflammatory response caused by infection with any of a wide variety of microorganisms. Clinically, it is characterized by fever, hypotension, and signs of organ hypoperfusion or dysfunction. The high mortality rate of septic shock, despite the administration of effective antimicrobial agents, fluids, and catecholamine vasopressors, has led to an extensive effort to identify the microbial products, host mediators, and cell- activation mechanisms that trigger and fuel the clinical manifestations of this syndrome. As a result of this effort, our understanding of septic shock has grown exponentially. However, although therapies targeting newly discovered pathogenic mechanisms have been developed, none have as yet demonstrated clinical efficacy [1], One of the most interesting mediators recently implicated in septic shock is nitric oxide (NO).

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Authors
  1. R. L. Danner
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  2. J. Cobb
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  3. A. L. Van Dervort
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Editor information

Editors and Affiliations

  1. Department of Surgery, Beth Israel Hospital, 330 Brookline Avenue, 02215, Boston, MA, USA

    M. P. Fink

  2. Department of Anesthesiology and Intensive Care, Lariboisière University Hospital, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France

    Didier Payen

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© 1995 Springer-Verlag Berlin Heidelberg

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Danner, R.L., Cobb, J., Van Dervort, A.L. (1995). Nitric Oxide as a Mediator of Hypotension and Inflammation in Sepsis. In: Fink, M.P., Payen, D. (eds) Role of Nitric Oxide in Sepsis and ADRS. Update in Intensive Care and Emergency Medicine, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79920-4_11

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  • DOI: https://doi.org/10.1007/978-3-642-79920-4_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79922-8

  • Online ISBN: 978-3-642-79920-4

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