Malignant Lymphomas in Immunocompromised Hosts, in Particular with AIDS

  • Umberto Tirelli
  • Emanuela Vaccher
Conference paper
Part of the ESO Monographs book series (ESO MONOGRAPHS)

Abstract

Prior to the AIDS epidemic, malignant lymphomas, in particular non-Hodgkin’s lymphoma (NHL), were described in up to 30% of the patients with primary immunodeficiency disorders such as the X-linked lymphoproliferative syndrome or the Wiscott Aldrich syndrome. Moreover, patients with immune deficiency secondary to cytostatic anticancer therapy and also following organ transplantation, autoimmune diseases and connective tissue disorders are at increased risk of NHL The lymphomas which arise in all these settings and in patients with HIV infection have certain features in common, including 1) prevalence of high-grade pathological types, predominantly large cell and immunoblastic lymphomas, or small non-cleaved cell; 2) restriction to B-cell origin; 3) widely disseminated disease at presentation; 4) poor prognosis compared to patients with “common” lymphomas.

Keywords

Oncol Doxorubicin Methotrexate Neutropenia Cyclophosphamide 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Umberto Tirelli
    • 1
  • Emanuela Vaccher
    • 1
  1. 1.Division of Medical Oncology and AIDSCentro di Riferimento OncologicoItaly

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