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Malignant Lymphomas: Biology and Treatment pp 179–189Cite as

Malignant Lymphomas in Immunocompromised Hosts, in Particular with AIDS

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Part of the book series: ESO Monographs ((ESO MONOGRAPHS))

Abstract

Prior to the AIDS epidemic, malignant lymphomas, in particular non-Hodgkin’s lymphoma (NHL), were described in up to 30% of the patients with primary immunodeficiency disorders such as the X-linked lymphoproliferative syndrome or the Wiscott Aldrich syndrome. Moreover, patients with immune deficiency secondary to cytostatic anticancer therapy and also following organ transplantation, autoimmune diseases and connective tissue disorders are at increased risk of NHL The lymphomas which arise in all these settings and in patients with HIV infection have certain features in common, including 1) prevalence of high-grade pathological types, predominantly large cell and immunoblastic lymphomas, or small non-cleaved cell; 2) restriction to B-cell origin; 3) widely disseminated disease at presentation; 4) poor prognosis compared to patients with “common” lymphomas.

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Author information

Authors and Affiliations

  1. Division of Medical Oncology and AIDS, Centro di Riferimento Oncologico, via Pedemontana 12, 33081 Aviano, Italy

    Umberto Tirelli & Emanuela Vaccher

Authors
  1. Umberto Tirelli
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  2. Emanuela Vaccher
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Editor information

Editors and Affiliations

  1. National and Kapodistrian University of Greece School of Medicine Laikon General Hospital, Athens, 115 27, Greece

    Gerassimos Alexander Pangalis (Associate Professor in Haematology and Medicine, Visiting Clinical Associate Professor) (Associate Professor in Haematology and Medicine, Visiting Clinical Associate Professor)

  2. School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA

    Gerassimos Alexander Pangalis (Associate Professor in Haematology and Medicine, Visiting Clinical Associate Professor) (Associate Professor in Haematology and Medicine, Visiting Clinical Associate Professor)

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© 1995 Springer-Verlag Berlin Heidelberg

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Tirelli, U., Vaccher, E. (1995). Malignant Lymphomas in Immunocompromised Hosts, in Particular with AIDS. In: Pangalis, G.A. (eds) Malignant Lymphomas: Biology and Treatment. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79913-6_14

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  • DOI: https://doi.org/10.1007/978-3-642-79913-6_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79915-0

  • Online ISBN: 978-3-642-79913-6

  • eBook Packages: Springer Book Archive

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