Cytomegalovirus Disease: Hemopoietic Recovery and Immune Control of Pulmonary Infection After Bone Marrow Transplantation
Cytomegaloviruses (CMV) are grouped into the beta-subfamily of the Herpesviridae. The beta-herpesviruses are all strictly species-specific. The viral genome is a double-stranded linear DNA of ca. 230 kbp. With ca. 200 open reading frames it represents the highest coding capacity known for viruses (Mocarski 1993). The infectious virus particle, the virion, is composed of a DNA nucleoprotein core, an icosahedral capsid, a tegument and, as the outer frontier, an envelope, which contains several glycoproteins for its interaction with host cells permissive for infection. Human CMV is the prototype and is of clinical relevance. Murine CMV shows homologies, but also differences at the levels of genetic organisation, DNA sequence, and proteins. Despite the differences, as far as we can judge to date, the pathogenesis and characteristics of disease are fairly similar for the two viruses. Murine CMV infection has therefore been employed as an experimental model to study CMV pathogenesis in the immunocompromised host and the principles of immune control of the infection in the immunocompetent host (Koszinowski et al. 1990,1993).
KeywordsHPLC Pneumonia Thrombocytopenia Encephalitis Allo
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- Einsele H, Ljungman P (1993) New developments in the diagnosis, prophylaxis and therapy of cytomegalovirus infection in marrow transplant recipients. Bone Marrow Transplant 12 Suppl 4:85–87Google Scholar
- Hertenstein B, Hampl W, Bunjes D, Wiesneth M, Dunker C, Koszinowski UH, Heimpel H, Arnold R, Mertens T (1995) Impact of graft versus host disease prophylaxis by in vivo/ex vivo T cell depletion on cytomegalovirus infection and disease early after bone marrow transplantation. Bone Marrow Transplant (in press)Google Scholar
- Koszinowski UH, Reddehase MJ, Jonjic S (1993) The role of T-lymphocyte subsets in the control of cytomegalovirus infection. In: Thomas DB (ed) Viruses and the cellular immune response. Dekker, New York, pp 429–445Google Scholar
- Ljungman P, Einsele H (1995) Cytomegalovirus infection. Curr Opin Hematol (in press)Google Scholar
- Ljungman P, Griffiths P (1993) Definitions of cytomegalovirus infection and disease. Excerpta Med Int Congr Ser 1032:233–237Google Scholar
- Ljungman P, Engelhard D, Link H, Biron P, Brandt L, Brunet S, Cordonnier C, Debusscher L, De Laurenzi A, Kolb HJ, Messina C, Newland AC, Prentice HG, Richard C, Ruutu T, Tilg H, Verdonck L (1992) Treatment of interstitial pneumonitis due to cytomegalovirus with ganciclovir and intravenous immune globulin: experience of European bone marrow transplant group. Clin Infect Dis 14:831–835PubMedCrossRefGoogle Scholar
- Mocarski ES (1993) Cytomegalovirus biology and replication. In: Roizman B, Whitley RJ, Lopez C (eds) The human herpesviruses. Raven, New York, pp 173–226Google Scholar
- Schmidt C, Oettle H, Wilborn P, Jessen J, Timm H, Schwerdfeger R, Oertel J, Siegert W (1994) Demonstration of cytomegalovirus after bone marrow transplantation by polymerase chain reaction, virus culture and antigen detection in buffy coat leukocytes. Bone Marrow Transplant 13:71–75PubMedGoogle Scholar