Immunity or Tolerance of T Cells Induced by Peptides

  • H. Pircher
  • P. Aichele
Conference paper


Exposure of lymphocytes to antigen normally results in activation, clonal expansion, and acquisition of effector cell function. Pioneering experiments by Mitchison in 1964 [1], however, revealed that the antigen dose plays an important role in deciding whether protein administration induces or down-regulates an immune response. Since then, several additional factors such as route and frequency of antigen delivery, use of adjuvants, and kinetics of antigen release have been identified which determine whether antigen challenge activates or tolerizes lymphocytes.


Major Histocompatibility Complex Glutamic Acid Decarboxylase Major Histocompatibility Complex Molecule Cell Tolerance Lymphocytic Choriomeningitis 
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Copyright information

© Springer Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • H. Pircher
  • P. Aichele

There are no affiliations available

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