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Myc-Mediated Apoptosis

  • Chapter
Apoptosis

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 16))

Abstract

Mammalian cells contain an intron-less myc gene, such as the rat s-myc gene and human myc L2 gene, which are expressed in rat embryo chondrocytes and human testis, respectively. Our recent findings demonstrated that s-Myc expression suppresses the growth activity and tumorigenicity of glioma cells, indicating that s-Myc acts as a negative regulator in tumor growth. In addition, we found that s-Myc overexpression can effectively induce apoptotic cell death in human and rat glioma cells without serum deprivation, which is distinct from c-Myc-mediated apoptosis.

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Authors and Affiliations

  1. Biophysics Division, National Cancer Research Institute, Tsukiji 5-1-1, 104, Chuo-ku, Tokyo, Japan

    Y. Kuchino, A. Asai & C. Kitanaka

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  1. Y. Kuchino
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  2. A. Asai
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  3. C. Kitanaka
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Editors and Affiliations

  1. Dept. of Biophysics, National Cancer Center Research Institute, Tsukiji 5-Chome, Chuoko, Tokyo, Japan

    Y. Kuchino

  2. Abteilung für Angewandte Molekularbiologie, Universität Mainz, Institut für Physiologische Chemie, Duesbergweg 6, 55099, Mainz, Germany

    W. E. G. Müller

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© 1996 Springer-Verlag Berlin Heidelberg

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Kuchino, Y., Asai, A., Kitanaka, C. (1996). Myc-Mediated Apoptosis. In: Kuchino, Y., Müller, W.E.G. (eds) Apoptosis. Progress in Molecular and Subcellular Biology, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79850-4_7

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  • DOI: https://doi.org/10.1007/978-3-642-79850-4_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79852-8

  • Online ISBN: 978-3-642-79850-4

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