Synapse Formation and Alteration During Regeneration
Many interactions contribute to the formation of connections in developing and regenerating nervous systems. During critical periods in development, extrinsic influences interact with the timetable of intrinsic events to produce differentiated neurons and networks (Wall and Taghert 1991; Ushkaryov et al. 1992; White et al. 1992; Mimura 1993). Although the particular mix of intrinsic and extrinsic factors that guide differentiation and synapse formation differs for different animals and for different neurons in a given animal (Thomson 1990; Keshishian 1993), similarities in the molecular basis of synapse formation are becoming more and more apparent.
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