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Endothelin Receptor Antagonists as New Tools to Inhibit Endothelin induced Vasoconstriction in Humans: Comparison with Calcium Channel Blockers

  • Chapter
The Endothelium in Cardiovascular Disease

Abstract

Diseases of the cardiovascular system account for the majority of morbidity and mortality in Western countries. Most forms of cardiovascular disease are associated with impaired vascular function in the cerebral, coronary, renal or peripheral circulation. Enhanced intermittent and/or persistent vasoconstriction is one of the most important features of several forms of cardiovascular disease [1]. Indeed, hypertension is characterized by a persistent increase in vascular tone of resistance arteries. In coronary spasm, migraine and Raynaud’s phenomenon, focal spasms of larger arteries are responsible for the clinical symptoms. Enhanced coronary vasoconstriction also importantly determines the angina threshold in patients with atherosclerotic coronary artery disease. Similarly, in low-tension glaucoma, increased vascular tone has been accounted for vision field defects and loss of sight [2]. Cerebral vasospasm after subarachnoid hemorrhage is an important complication associated with high morbidity and mortality in patients [3].

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  1. R. R. Wenzel
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  2. T. F. Lüscher
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  1. Abteilung Kardiologie, Inselspital, 3010, Bern, Switzerland

    Thomas F. Lüscher

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Wenzel, R.R., Lüscher, T.F. (1995). Endothelin Receptor Antagonists as New Tools to Inhibit Endothelin induced Vasoconstriction in Humans: Comparison with Calcium Channel Blockers. In: Lüscher, T.F. (eds) The Endothelium in Cardiovascular Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79803-0_11

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  • DOI: https://doi.org/10.1007/978-3-642-79803-0_11

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