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The Role of CD4 in HIV Envelope-Mediated Pathogenesis

  • Chapter
The CD4 Molecule

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 205))

Abstract

The high affinity interaction between the envelope (env)glycoprotein of HIV-1 and the cell surface glycoprotein CD4 is a central molecular event in AIDS pathogenesis. This interaction not only provides the molecular basis for the tropism of HIV-1 for CD4+ cells, but, as is described in the present chapter, also represents a critical step in several cpmplex pathogenic mechanisms that contribute to the development of immunodeficiency in HIV-1-infected individuals.

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Authors and Affiliations

  1. Department of Medicine, 1049 Ross Building, Johns Hopkins University School of Medicine, 720 Rutland Avenue, 21205, Baltimore, MD, USA

    R. F. Siliciano

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  1. R. F. Siliciano
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  1. Howard Hughes Medical Institute, Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, 10016, New York, NY, USA

    Dan R. Littman M.D, Ph.D.

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© 1996 Springer-Verlag Berlin Heidelberg

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Siliciano, R.F. (1996). The Role of CD4 in HIV Envelope-Mediated Pathogenesis. In: Littman, D.R. (eds) The CD4 Molecule. Current Topics in Microbiology and Immunology, vol 205. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79798-9_8

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  • DOI: https://doi.org/10.1007/978-3-642-79798-9_8

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