The Role of CD4 in HIV Envelope-Mediated Pathogenesis

  • R. F. Siliciano
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 205)


The high affinity interaction between the envelope (env)glycoprotein of HIV-1 and the cell surface glycoprotein CD4 is a central molecular event in AIDS pathogenesis. This interaction not only provides the molecular basis for the tropism of HIV-1 for CD4+ cells, but, as is described in the present chapter, also represents a critical step in several cpmplex pathogenic mechanisms that contribute to the development of immunodeficiency in HIV-1-infected individuals.


Human Immunodeficiency Virus Acquire Immune Deficiency Syndrome Cytopathic Effect Syncytium Formation Acquire Immune Deficiency Syndrome Patient 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • R. F. Siliciano
    • 1
  1. 1.Department of Medicine, 1049 Ross BuildingJohns Hopkins University School of MedicineBaltimoreUSA

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