Endocytic and Exocytic Regulation of CD4 Expression and Function

  • M. Marsh
  • A. Pelchen-Matthews
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 205)


CD4 is one of the plethora of glycoprotein and glycolipid antigens expressed on the surfaces of lymphocytes (Barclay et al. 1993). Many of these antigens are involved in the development and control of lymphocyte function and, as a consequence, their expression at the cell surface must be tightly regulated. Regulation can occur either at the levels of transcription and translation (see, for example, Sawada et al. 1994) or, alternatively, through the posttranslational activities of the exocytic and endocytic pathways. Here we discuss the processes that operate posttranslationally. In particular we review the interaction of CD4 with the endocytic pathway and discuss how the endocytic properties of CD4 may: (1) function in regulating T cells, and (2) relate to broader issues of membrane trafficking.


Human Immunodeficiency Virus Human Immunodeficiency Virus Type Cytoplasmic Domain Phorbol Ester Nonlymphoid Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • M. Marsh
    • 1
  • A. Pelchen-Matthews
    • 1
  1. 1.Medical Research Council Laboratory for Molecular Cell Biology, and Department of BiochemistryUniversity College LondonLondonUK

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