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The Regulation and Function of the CD4 Coreceptor During T Lymphocyte Development

  • N. Killeen
  • D. R. Littman
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 205)

Abstract

The progression of thymocytes through sequential developmental stages is marked by an ordered pattern of expression of many different cell surface molecules (Kruisbeek 1993). Of these, the CD4 and CD8 glycoproteins are noteworthy because their differential expression defines the two major lineages of mature peripheral T cells (Swain 1983). Although mature cells express one molecule or the other, the large majority of immature thymocytes expresses both CD4 and CD8. These double positive (DP) cells are subjected to a stringent selection process which favors survival of the few cells that can interact productively with host MHC molecules (Hogquist et al. 1994; von Boehmer 1994). Down-regulation of either CD4 or CD8 accompanies positive selection and precedes the emergence of mature cells with distinct effector functions.

Keywords

Double Positive Thymic Selection Thymocyte Development Double Positive Thymocyte Thymocyte Selection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • N. Killeen
    • 1
  • D. R. Littman
    • 2
  1. 1.Department of Microbiology and ImmunologyUniversity of California at San FranciscoSan FranciscoUSA
  2. 2.Molecular Pathogenesis Program and The Howard Hughes Medical Institute, The Skirball Institute of Biomolecular MedicineNew York University Medical CenterNew YorkUSA

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