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Signal Transduction by the Lymphocyte-Specific Tyrosine Protein Kinase p56lck

  • R. Weil
  • A. Veillette
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 205)

Abstract

Stimulation of T Lymphocytes by antigen or anti-T cell receptor (TCR) antibodies provokes a rapid series of intracellular biochemical changes, leading to the expression of either the helper-inducer or the cytotoxic T cell phenotype (for reviews, see Samelson and Klausner 1992; Veillette and Davidson 1992; Perlmutter et al. 1993 and Weiss and Littman 1994). This response, termed T cell activation, is accompanied by a sudden increase in intracellular phosphotyrosine levels. Importantly, the use of tyrosine protein kinase inhibitors has revealed that tyrosine protein phosphorylation is required for all subsequent events of T cell activation, including stimulation of phosphatidyl inositol (PI) turnover, rise in intracellular calcium, lymphokine secretion and mitogenesis (Mustelin et al. 1990; June et al. 1990).

Keywords

Tyrosine Phosphorylation Tyrosine Protein Kinase Tyrosine Protein Phosphorylation Cell Antigen Receptor Antigen Receptor Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • R. Weil
    • 1
  • A. Veillette
    • 1
    • 2
    • 3
  1. 1.McGill Cancer Centre, Mclntyre Medical Sciences BuildingMcGill UniversityMontrealCanada
  2. 2.Departments of Biochemistry, Medicine, and Oncology, Mclntyre Medical Sciences BuildingMcGill UniversityMontrealCanada
  3. 3.Departments of Medicine and OncologyMontreal General HospitalMontrealCanada

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