Signal Transduction by the Lymphocyte-Specific Tyrosine Protein Kinase p56lck

  • R. Weil
  • A. Veillette
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 205)


Stimulation of T Lymphocytes by antigen or anti-T cell receptor (TCR) antibodies provokes a rapid series of intracellular biochemical changes, leading to the expression of either the helper-inducer or the cytotoxic T cell phenotype (for reviews, see Samelson and Klausner 1992; Veillette and Davidson 1992; Perlmutter et al. 1993 and Weiss and Littman 1994). This response, termed T cell activation, is accompanied by a sudden increase in intracellular phosphotyrosine levels. Importantly, the use of tyrosine protein kinase inhibitors has revealed that tyrosine protein phosphorylation is required for all subsequent events of T cell activation, including stimulation of phosphatidyl inositol (PI) turnover, rise in intracellular calcium, lymphokine secretion and mitogenesis (Mustelin et al. 1990; June et al. 1990).


Tyrosine Phosphorylation Tyrosine Protein Kinase Tyrosine Protein Phosphorylation Cell Antigen Receptor Antigen Receptor Complex 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • R. Weil
    • 1
  • A. Veillette
    • 1
    • 2
    • 3
  1. 1.McGill Cancer Centre, Mclntyre Medical Sciences BuildingMcGill UniversityMontrealCanada
  2. 2.Departments of Biochemistry, Medicine, and Oncology, Mclntyre Medical Sciences BuildingMcGill UniversityMontrealCanada
  3. 3.Departments of Medicine and OncologyMontreal General HospitalMontrealCanada

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