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CD4 and Signal Transduction

  • K. S. Ravichandran
  • T. L. Collins
  • S. J. Burakoff
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 205)

Abstract

CD4 is a 55–60 kDa monomeric glycoprotein expressed on approximately 60% of peripheral blood T lymphocytes (Reinherz et al. 1979; Terhorst et al. 1980). Originally identified as a phenotypic marker (Reinherz et al. 1979; Webb et al. 1979; Dialynas et al. 1983), a role for CD4 in the activation of T lymphocytes was indicated when anti-CD4 antibodies inhibited a variety of T lymphocyte effector functions in vitro (Krensky et al. 1982; Spits et al. 1982; Wilde et al. 1983; Rogozinski et al. 1984). It was later demonstrated that CD4 facilitates T lymphocyte function by binding to the nonpolymorphic region of the major histocompatibility (MHC) class II antigens expressed on the surface of antigen presenting cells (APCs) (Doyle and Strominger 1987; Sleckman et al. 1987; Gay et al. 1988; Cammarota et al. 1992; König et al. 1992). The interaction between CD4 and MHC class II molecules have proven to be critical for antigen responsiveness of CD4+T cells (Gay et al. 1987; Sleckman et al. 1987).

Keywords

Tyrosine Phosphorylation Tyrosine Kinase Activity Cell Antigen Receptor Nucleotide Exchange Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • K. S. Ravichandran
    • 1
  • T. L. Collins
    • 1
  • S. J. Burakoff
    • 1
    • 2
  1. 1.Division of Pediatric OncologyDana-Farber Cancer InstituteBostonUSA
  2. 2.Department of PediatricsHarvard Medical SchoolBostonUSA

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