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The Structure of CD4

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Book cover The CD4 Molecule

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 205))

Abstract

The CD4 antigen was first identified by the W3/25 monoclonal antibody (mAb) in the rat and indeed was one of the first lymphocyte cell surface antigens to be defined by monoclonal antibodies in any species (Williams et al. 1977). The W3/25 mAb was of particular interest as it was the first marker for the sub-population of T lymphocytes with “helper” activity (White et al. 1978). The human homologue of the W3/25 antigen was identified with the mAb T4 (Reinherz et al. 1979) and later termed CD4. The CD (clusters of differentiation) nomenclature was introduced as a simple method to group together mAbs that recognised the same antigen at the surface of human leucocytes (Bernard et al. 1984). This nomenclature is now widely used to describe both the antibody recognising the antigen and the antigen itself. It is also used to describe homologues in species other than humans.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Bristol, University Walk, BS8 1TD, Bristol, UK

    R. L. Brady

  2. MRC Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK

    A. N. Barclay

Authors
  1. R. L. Brady
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  2. A. N. Barclay
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Editor information

Editors and Affiliations

  1. Howard Hughes Medical Institute, Division of Molecular Pathogenesis, Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, 10016, New York, NY, USA

    Dan R. Littman M.D, Ph.D.

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© 1996 Springer-Verlag Berlin Heidelberg

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Brady, R.L., Barclay, A.N. (1996). The Structure of CD4. In: Littman, D.R. (eds) The CD4 Molecule. Current Topics in Microbiology and Immunology, vol 205. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79798-9_1

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  • DOI: https://doi.org/10.1007/978-3-642-79798-9_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79800-9

  • Online ISBN: 978-3-642-79798-9

  • eBook Packages: Springer Book Archive

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