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Hepatokarzinogenese bei Hepadnaviren und im transgenen Mausmodell

  • H.-J. Schlicht
  • E. Schmitteckert
  • K. Reifenberg
Conference paper

Zusammenfassung

Es ist seit langem unbestritten, daß eine chronische Infektion mit dem humanpathogenen Hepatitis-B-Virus (HBV) eine Leberzirrhose und auch ein primäres hepatozelluläres Karzinom verursachen kann. Welche Eigenschaften des Virus für diese Spätfolgen der Infektion verantwortlich sind, liegt aber noch weitgehend im Dunkeln. In dieser kurzen Übersicht sollen die wichtigsten Hypothesen zur Entstehung von Lebertumoren nach HBV-Infektion diskutiert und einige der experimentellen Ansätze, die zur Klärung dieser zentralen Frage beitragen können, vorgestellt werden.

Summary

It is generally accepted that a chronic hepatitis B virus infection can result in liver cirrhosis and primary hepatocellular carcinoma. However, it is still unclear which characteristics of the virus are responsible for cancerogenesis. In this brief review the most important hypotheses of HBV-induced liver cancer are discussed and some of the experimental strategies which could help to clarify this point are presented.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • H.-J. Schlicht
  • E. Schmitteckert
  • K. Reifenberg

There are no affiliations available

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