Skip to main content

Beurteilung des Radikalstoffwechsels und Effizienz angewandter Meßmethoden

  • Conference paper
Book cover Oxidativer Stress in der Kinderheilkunde
  • 26 Accesses

Zusammenfassung

Unter physiologischen Bedingungen entstehen Sauerstoffradikale endogen durch die Reduktion von Sauerstoff im Verlauf der mitochondrialen Atmung, bei der Phagozytose im Rahmen der Infektabwehr, im Eicosanoidstoffwechsel, bei enzymkatalysierten Prozessen und im Verlauf der Autoxidation verschiedener Moleküle.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Aebi H (1974) Katalase. In: Bergmeyer HU (Hrsg.) Methoden der enzymati-schen Analyse, Bd I, Verlag Chemie, Weinheim, 713–727.

    Google Scholar 

  • Bartens C, Götz M, Urbanek R, Elmadfa I (1994) Antioxidanzienstatus bei Patienten mit zystischer Fibrose (CF) und hohem Immunglobulin G (IgG)-Gehalt im Plasma. Akt Ernähr-Med 19:52

    Google Scholar 

  • Beutler E (1984) Glutathion peroxidase. In: Beutler E (ed) Red cell metabolism. A mannual of biochemical methods. Grune & Straton, New York

    Google Scholar 

  • Boat TF, Cheng PW (1989) Epithelial cell dysfunction in cystic fibrosis: implications for airway disease. Acta Pediatr Scand 363:25–30

    CAS  Google Scholar 

  • Buettner G, Mason R (1991) Spin-trapping methods for detecting superoxide and hydroxyl free radicals in vitro and in vivo. Methods Enzymol 186:127–132.

    Article  Google Scholar 

  • Chio KS, Tappel A (1969) Synthesis and characterization of the fluorescent products derived from malonaldehyde and amino acids. Biochemistry 8:2812–2827

    Google Scholar 

  • Cleeter MWJ, Cooper MJ, Schapira AHV (1992) Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: Evidence for free radical involvement. J Neurochem 58(2):786–789

    Article  PubMed  CAS  Google Scholar 

  • Corongiu FP, Poli G, Dianzani MU et al. (1986) Lipid peroxidation and molecular damage to polyunsaturated fatty acids in rat liver: recognition of two classes of hydroperoxides formed under conditions in vivo: Chem Biol Interact 59:147–155

    Article  PubMed  CAS  Google Scholar 

  • Elmadfa I, Bosse W (1985) Vitamin E: Eigenschaften, Wirkungsweise und therapeutische Bedeutung. S. 13–25, Wissenschaftl. Verlagsgesellschaft, Stuttgart

    Google Scholar 

  • Evans RM, Currie L, Campbell A (1982) The distribution of ascorbic acid between various cellular components of blood in normal individuals and its relation to the plasma concentration. Brit J Nutr 47:473–481

    Article  PubMed  CAS  Google Scholar 

  • Faist V, König J, Höger H, Elmadfa I (1993) On the adaptability of mice with duchenne muscular dystrophy to physical exercise: formation and release of free radicals from muscle mitochondria. In: Nohl H, Esterbauer H (eds) International conference on critical aspects of free radicals in chemistry, biochemistry and medicine. Book of abstracts. Österreichische Staatsdruckerei, Wien, p 82

    Google Scholar 

  • Fiegin RD, Shackelford PG, Choi SC et al. (1971) Nitroblue tetrazolium dye test as an aid for the different diagnosis of fabrille disorders. J Pediatr 78:230–235

    Article  Google Scholar 

  • Floyd RA (1990) Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J 4:2587–2597

    PubMed  CAS  Google Scholar 

  • Glazer A (1990) Phycoerythrin fluorescence-based assay for reactive oxygen species. Methods Enzymol 186:161–167

    Article  PubMed  CAS  Google Scholar 

  • Greenwald RA, Rush SW, Moak SA, Weitz Z (1989) Conversion of superoxide generated by polymorphonuclear leukocytes to hydroxyl radical: A direct spectrophotometric detection system based on the degradation of desoxyribose. Free Radic Biol Med 6:385–392

    Article  PubMed  CAS  Google Scholar 

  • Halliwell B, Gutteridge JMC (1989) Free radicals in biology and medicine, 2nd edn. Oxford University Press, Oxford

    Google Scholar 

  • Harman D (1986) Free radical theory of aging: role of free radicals in the origination and evolution of life, aging, and disease processes. In: Johnson JE, Walford R, Harman D, Miquel D (eds) Free radicals, aging and degenerative diseases. Alan R Liss, New York, pp 3–49

    Google Scholar 

  • Holtzmann JL (ed) (1984) Spin-labelling in pharmacology. Academic Press, New York

    Google Scholar 

  • Jakob E, Elmadfa I (1994a) Rapid HPLC assay for the assessment of vitamin K1, A, E and beta-carotene status in children (7–19 years). Int J Vit Nutr Res 65:31–35

    Google Scholar 

  • Jakob E, Elmadfa I (1994b) Korrelation zwischen Vitamin E, K und β-Caro-tin bei Mukoviszidose- und Diabetes-mellitus-Patienten. Akt Ernähr-Med 19:65

    Google Scholar 

  • Kappus H (1982) Toxizität von Sauerstoffradikalen — Biologische Funktion und schädliche Wirkung auf das Gewebe. In: Puhl W, Sies H (Hrsg) Abakterielle, artikuläre und perartikuläre Entzündungen. Perimed Fachbuch, Verlagsgesellschaft Erlangen

    Google Scholar 

  • Kreinhoff U, Elmadfa I, Salomon F, Weidler B (1990) Untersuchungen zum Antioxidantienstatus nach operativem Stress. Infusionstherapie 17: 261–267

    PubMed  CAS  Google Scholar 

  • Linnane AW, Marzuki S, Ozawa T, Tanaka M (1989) Mitochondrial DNA mutations as an important contributor to aging and degenerative disease. Lancet 3(i):642–645

    Article  Google Scholar 

  • Loschen G, Azzi A, Flohe L (1973) Mitochondrial H2O2 formation: relationship with energy formation. FEBS LETT 33:84–88

    Article  PubMed  CAS  Google Scholar 

  • Marklund S, Marklund G (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and convenient assay for superoxide dismutase. Eur J Biochem 47:469–474

    Article  PubMed  CAS  Google Scholar 

  • Meyer KC, Lewandoski Zimmermann JR et al. (1991) Human neutrophile elastase and elastase/alpha 1 antiprotease complex in cystic fibrosis. Am Rev Respir Dis 144:580–585

    Article  PubMed  CAS  Google Scholar 

  • Miki T, Yu L, Yu CA (1992) Characterization of ubisemichinone radicals in succinate-ubichinone reductase. Arch Biochem Biophys 293(1):61–66

    Article  PubMed  CAS  Google Scholar 

  • Nohl H, Jordan W (1986) The mitochondrial site of superoxide formation. Biochem Biophys Res Comm 138(2):533–539

    Article  PubMed  CAS  Google Scholar 

  • Packer L (1991) Protective role of vitamin E in biological systems. Am J Clin Nutr 53 (4 Suppl):1050S–1055S

    PubMed  CAS  Google Scholar 

  • Pendleton RB, Lands WEM (1987) Assay of lipid hydroperoxides by activation of cyclooxygenase activity. Free Radic Biol Med 3:337–339

    Article  PubMed  CAS  Google Scholar 

  • Pryor WA (1973) Free radical reactions and their importance in biological systems. Federation Proceedings 32:1862–1869.

    PubMed  CAS  Google Scholar 

  • Rice-Evans CA, Diplock AT, Symons MCR (1991) Techniques in free radical research. In: Burdon RH, Knippenberg PH van (eds) Laboratory techniques in biochemistry and molecular biology, vol 22, Elsevier, Amsterdam, pp 76–85

    Google Scholar 

  • Sierakowski B, Elmadfa I (1987) Wie verhalten sich Retinol- und Tocophe-rolkonzentrationen im Plasma von Probanden während parenteraler Verabreichung verschiedener Fettemulsionen. Akt Ernähr-Med 12:93–96

    CAS  Google Scholar 

  • Sohal RS, Donato H (1979) Effect of experimental prolongation of life span on lipofuscin content and lysosomal enzyme activity in the brain of the housefly, Musca domestica. Exp Gerontol 13:335–341

    Article  Google Scholar 

  • Taylor AE, Martin D, Parker JC (1983) The effects of oxygen radicals on pulmonary edema formation. Surgery 94:433–438

    PubMed  CAS  Google Scholar 

  • Wong S, Knight J, Hopfer S et al. (1987) Lipoperoxide in plasma as measured by liquid-chromatographic separation of malondialdehyde thiobarbitu-ric acid adduct. Clin Chem 33:214–220

    PubMed  CAS  Google Scholar 

  • Wood RE, Boat TF, Doershuk CF (1976) Cystic fibrosis. Am Rev Respir Dis 113:833–878

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Elmadfa, I., Faist, V. (1995). Beurteilung des Radikalstoffwechsels und Effizienz angewandter Meßmethoden. In: Böhles, H. (eds) Oxidativer Stress in der Kinderheilkunde. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79748-4_8

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-79748-4_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-59256-3

  • Online ISBN: 978-3-642-79748-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics