Lipidperoxidation bei Mangelernährung

  • M. Leichsenring
Conference paper


Ein wesentlicher Teil der antioxidativ wirksamen Schutzsysteme des Menschen ist von Substanzen abhängig, die mit der Nahrung aufgenommen werden (Wills 1985). Dazu gehören z. B. Vitamine und Provitamine wie Tokopherol, Askorbat oder die Karotinoide. Es ist also begründet anzunehmen, daß schwere Mangelernährung (Protein-Energie-Malnutrition; PEM) mit verminderter antioxidativer Kapazität, erhöhtem oxidativem Streß (OS) und vermehrter Lipidperoxidation (LPO) einhergeht.


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  1. Ahmded HM, Lombeck I, el Karib AO et al. (1989) Selenium status in Sudanese children with protein-calorie malnutrition. J Trace Elem Electrolytes Health Dis 3:171–174Google Scholar
  2. Ahmed HM, Laryea MD, el Karib AO et al. (1990) Vitamin E status in Sudanese children with protein-energy malnutrition. Z Ernahrungswiss 29:47–53PubMedCrossRefGoogle Scholar
  3. Becker K, Bötticher D, Leichsenring M (1994) Antioxidant vitamins in malnourished Nigerian children. Internat J Vit Nutr Res 64:306–310Google Scholar
  4. Becker K, Leichsenring M, Gana I et al. (in press) Glutathione and associated antioxidant systems in protein energy malnutrition: Results of a study in Nigeria. Free Rad Biol MedGoogle Scholar
  5. Beyer RE (1990) The participation of coenzyme q in free radical production and anti-oxidation. Free Rad Biol Med 8:545–565PubMedCrossRefGoogle Scholar
  6. Bhattacharyya AK (1986) Protein-energy malnutrition (Kwashiorkor-Marasmus syndrome): terminology, classification and evolution. World Rev Nutr Diet 47:80–133PubMedGoogle Scholar
  7. Esterbauer H, Schaur RJ, Zollner H (1991) Chemistry and biochemistry of 4-hydrosynonenal, malonaldehyde and related aldehydes. Free Rad Biol Med 11:81–128PubMedCrossRefGoogle Scholar
  8. Farrell PM, Levine SL, Murphy MD, Adams AJ (1978) Plasma tocopherol levels and tocopherol-lipid relationships in a normal population of children as compared to healthy adults. Am J Clin Nutr 31:1720–1726PubMedGoogle Scholar
  9. Forrester T, Golden M, Brand S, Swales J (1990) Reduction in vitro of red cell glutathione reproduces defects of cellular sodium transport seen in oedematous malnutrition. Eur J Clin Nutr 44:363–369PubMedGoogle Scholar
  10. Golden MHN (1985) The consequences of protein deficiency in man and its relationship to the features of kwashiorkor. In: Blaxter K, Waterlow JC (eds) Nutritional adaptation in man. John Libbey, London, Paris, pp 169–187Google Scholar
  11. Golden MH, Ramdath D (1987) Free radicals in the pathogenesis of kwashiorkor. Proc Nutr Soc 46:53–68PubMedCrossRefGoogle Scholar
  12. Gopalan C (1968) Kwashiorkor and marasmus: evolution and distinguishing features. In: McCanca RA, Widdowson EM (eds) Calorie deficiencies and protein deficiencies. Boston, pp 49–58Google Scholar
  13. Halliwell B (1988) Albumin — an important extracellular antioxidant? Biochem Pharmacol 37:569–571PubMedCrossRefGoogle Scholar
  14. Hendrickse RG, Coulter JBS, Lamplugh SM (1982) Aflatoxins and kwashiorkor: a study in Sudanese children. Br Med J 285:843–846CrossRefGoogle Scholar
  15. Holley AE, Walker MK, Cheeseman KH, Slater TF (1993) Measurement of n-alkanals and hydroxyalkenals in biological samples. Free Radie Biol Med 15:281–289CrossRefGoogle Scholar
  16. Holman RT, Johnson SB, Mercuri O et al. (1981) Essential fatty acid deficiency in malnourished children. Am J Clin Nutr 34:1534–1539PubMedGoogle Scholar
  17. Househam KC, Hundt HKL (1991) Aflatoxin exposure and its relationship to kwashiorkor in African children. J Trop Pediatr 37:300–302PubMedGoogle Scholar
  18. Ingold KU, Webb AC, Witter D et al. (1987) Vitamin E remains the major lipid-soluble, chain-breaking antioxidant in human plasma even in individuals suffering severe vitamin E deficiency. Arch Biochem Biophys 259:224–225PubMedCrossRefGoogle Scholar
  19. Janero DR (1990) Malondialdehyde and thiobarituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Rad Biol Med 9:515–540PubMedCrossRefGoogle Scholar
  20. Kohlmüller D, Kochen W (1993) Is n-pentane really an index of lipid peroxidation in humans and animals? A methodological reevalution. Anal Biochem 210:268–276PubMedCrossRefGoogle Scholar
  21. Kohlmüller, D, Less S, Kochen W (1993) Exhalation air analysis in humans: Reevaluation of the significance of n-pentane in lipid peroxidation. Alpe Adria J Med XLVIII:169–183Google Scholar
  22. Koletzko B, Abiodun PO, Laryea MD, Bremer HJ (1986) Fatty acid composition of plasma lipids in Nigerian children with protein-energy malnutrition. Eur J Pediatr 145:109–115PubMedCrossRefGoogle Scholar
  23. Kosugi H, Kojima T, Kikugawa K (1989) Thiobarbituric acid-reactive substances from peroxidized lipids. Lipids 24:873–881CrossRefGoogle Scholar
  24. Kosugi H, Kikugawa K (1989) Potential thiobarbituric acid-reactive substances in peroxidized lipids. Free Radic Biol Med 7:205–207PubMedCrossRefGoogle Scholar
  25. Laryea MD, Mayatepek E, Brünninger P et al. (1990) Vitamin E status of Congolese children in a rural area. Int J Vit Nutr Res 60:107–111Google Scholar
  26. Leichsenring M, Ahmed HM, Weichering T et al. (1992a) Polyunsaturated and essential fatty acids in malnourished children. Nutr Res 12:595–603CrossRefGoogle Scholar
  27. Leichsenring M, Bremer HJ, Ahmed HM et al. (1992b) Clinical studies on polyunsaturated fatty acids and antioxidants in African children. In: Packer L, Ong ASH (eds) Lipid-soluble antioxidants: biochemistry and clinical applications. Birkhäuser, Basel Boston Berlin, pp 507–515Google Scholar
  28. Leichsenring M, Hardenack M, Laryea MD (1992c) Relationship among the fatty acid composition of various lipid fractions in normally nourished German adults. Int J Vit Nutr Res 62:181–185Google Scholar
  29. Leichsenring M, Sütterlin N, Less S et al. (in press) Polyunsaturated fatty acids in erythrocyte and plasma lipids of children with severe protein-energy malnutrition. Acta PaediatrGoogle Scholar
  30. Lepage G, Munoz G, Champagne J, Roy CC (1991) Preparative steps necessary for the accurate measurement of malondialdehyde by high-performance liquid chromatography. Anal Biochem 197:277–283PubMedCrossRefGoogle Scholar
  31. Marin MC, De Tomas ME, Mercuri O et al. (1991) Interrelationship between protein-energy malnutrition and essential fatty acid deficiency in nursing infants. Am J Clin Nutr 53:466–468PubMedGoogle Scholar
  32. Mathias PM, Jackson AA (1982) Selenium deficiency in kwashiorkor [letter]. Lancet 1:1312–1313PubMedCrossRefGoogle Scholar
  33. Mayatepek E, Becker K, Gana L et al. (1993) Leukotrienes in the pathophysiology of kwashiorkor. Lancet 342:958–960PubMedCrossRefGoogle Scholar
  34. McLaren DS, Shirajian E, Loshkajian H, Shadarevian S (1969) Short-term prognosis in protein-calorie malnutrition. Am J Clin Nutr 22:863–870PubMedGoogle Scholar
  35. Mukherjee B, Mukherjee JR, Chatterjee M (1994) Lipid peroxidation, glutathione levels and changes in glutathione-related enzyme activities in streptozotocin-induced diabetic rats. Immunol Cell Biol 72:109–114PubMedCrossRefGoogle Scholar
  36. Oshaug A, Pedersen J, Diarra M et al. (1994) Problems and pitfalls in the use of estimated age in anthropometric measurements of children from 6 to 60 months of age: A case from Mali. J Nutr 124:636–644PubMedGoogle Scholar
  37. Samuelsson B, Dahlen SE, Lindgren JA et al. (1987) Leukotrienes and lipoxins: structures, biosynthesis and biological effects. Science 237: 1171–1176PubMedCrossRefGoogle Scholar
  38. Schroeder DG, Brown KH (1994) Nutritional status as a predictor of child survival: Summarizing the association and quantifying its global impact. Bull World Health Organ 72:569–579PubMedGoogle Scholar
  39. Sive AA, Subotzky EF, Malan H et al. (1993) Red blood cell antioxidant enzyme concentrations in kwashiorkor and marasmus. Ann Trop Paediatr 13:33–38PubMedGoogle Scholar
  40. Vajreswari A, Narayanareddy K, Rao PS (1992) Fatty acid composition of erythrocyte membrane lipid obtained from children suffering from kwashiorkor and marasmus. Metabolism 39:779–782CrossRefGoogle Scholar
  41. Wellcome Trust Working Party (1970) Classification of infantile malnutrition. Lancet II:302–303Google Scholar
  42. Williams CD (1933) Nutritional disease of childhood associated with maize diet. Arch Dis Child 8:423–433PubMedCrossRefGoogle Scholar
  43. Williams CD (1935) Kwashiorkor. A nutritional disease of children associated with a maize diet. Lancet II:1151–1152CrossRefGoogle Scholar
  44. Wills ED (1985) The role of dietary components in oxidative stress in tissues. In: Sies H (ed) Oxidative stress. Academic Press, London, pp 197–218Google Scholar
  45. Wolff JA, Margolis S, Bujdoso-Wolff K et al. (1984) Plasma and red blood cell fatty acid composition in children with protein-calorie malnutrition. Pediatr Res 18:162–167PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1995

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  • M. Leichsenring

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