Pathogenesis and Detection of Oxygen Toxicity in the Newborn
Reactive oxygen species (ROS) comprise a large variety of inorganic and organic oxygen-derived compounds, i.e., superoxide radical (∙O2), hydrogen peroxide (H2O2), hydroxyl radical (∙OH), hypochlorous acid (HOCl), nitric oxide radical (∙NO), and alkoxyl (RO∙), and peroxyl radicals (ROO∙; Gutteridge 1989). ∙NO reacts rapidly with ∙O2 to form the strong oxidant, the peroxynitrite anion (ONOO-) (Beckman et al. 1994).
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