Therapie von Lungenerkrankungen mit Antioxidanzien

  • R. Buhl
  • J. Bargon
  • W. Caspary
Conference paper

Zusammenfassung

Freie Radikale sind Atome oder Moleküle mit einem oder mehreren unpaaren Elektronen und dadurch ausgeprägter Reaktionsfähigkeit. Vom Sauerstoffmolekül abgeleitete freie Radikale werden auch als Oxidanzien bezeichnet. Beide Begriffe werden oft synonym gebraucht, da medizinisch relevante freie Radikale meist reaktive Sauerstoffspezies oder daraus entstehende Verbindungen sind. Durch ihre extreme Reaktivität können Oxidanzien die Struktur und damit die Funktion nahezu aller Zielmoleküle verändern. Zellen können irreversibel geschädigt werden, indem Oxidanzien strukturelle Bestandteile angreifen, mit vitalen Stoffwechselprozessen interferieren oder die DNA verändern. Die extrazelluläre Inak-tivierung wichtiger Moleküle kann indirekt Schäden hervorrufen (Schraufstätter u. Cochrane 1991; Warren et al. 1991).

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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • R. Buhl
  • J. Bargon
  • W. Caspary

There are no affiliations available

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