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Schizophrenie pp 1–29Cite as

Molekulare Grundlagen der Interaktion zwischen Dopamin-(D1-/D2-)Rezeptoren

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Zusammenfassung

Zahlreiche objektive und subjektive psychomotorische Symptome werden von der Aktivität dopaminerger Neurone und von Pharmaka beeinflußt, die selektiv mit den neuronalen Dopaminrezeptoren in Wechselwirkung treten (Davis et al. 1991; Goldstein u. Deutsch 1992). Zu den Symptomen gehören der Rigor bei Parkinson-Krankheit, Halluzinationen bei Schizophrenie und Alzheimer-Krankheit sowie Dyskinesien bei Chorea Huntington und spontane orale Dyskinesien im Alter (Seeman 1987; Seeman u. Niznik 1990). Die Dopaminrezeptoren wurden anhand biochemischer, pharmakologischer und physiologischer Kriterien in 2 Klassen eingeteilt, die mit D1 und D2 bezeichnet wurden (Kebabian u. Caine 1979; Seeman 1980; Niznik 1987; Niznik u. Jarvie 1989; Kebabian 1993; Hall 1994). Die Dopaminrezeptoren gehören zu einer großen Genfamilie von Hormon-/ Neurotransmitterrezeptoren, die ihre biologischen Wirkungen über bestimmte Signaltransduktionsmechanismen entfalten, an denen die Bindung von Guaninnukleotiden bzw. G-Proteine beteiligt sind (s. Kaziro et al. 1991; Simon et al. 1991; Hille 1992; Clapham u. Neer 1993). D2-Dopaminrezeptoren hemmen die Aktivität der Adenylatzyklase und scheinen die zahlreichen anderen Effektorsysteme miteinander zu koppeln (Dal Toso et al. 1989; Neve et al. 1989; Albert et al. 1990; Senogles et al. 1990; Vallar et al. 1990; Kanterman et al. 1991; Elsholtz et al. 1991; Castellano et al. 1993; Lledo et al. 1994), indem sie spezifische Subtypen von G-Proteinen aktivieren (Lledo et al. 1992; Missalle et al. 1991; Burris et al. 1992).

Danksagung: Die Autoren möchten H. C. Guan, A. Tirpak, C. Ulpian, F. McConkey und K. Ohara für ihre technische Unterstützung und Dr. Philip Seeman für seine ständigen Ermutigungen und kompetenten Anmerkungen im Verlaufe dieser Experimente danken. Diese Arbeit wurde zu einem Teil unterstützt durch den Established-Investigator-Förderpreis der National Alliance for Research in Schizophrenia and Depression (NARSAD) sowie durch Zuschüsse des National Institute of Drug Abuse (DA07223-02), des kanadischen Medical Research Council (PG-11121), der Ontario Mental Health Foundation und der Ontario Friends of Schizophrenics an H. B. Niznik und das Clarke Institute of Psychiatry. R. K. Sunahara wurde durch Postgraduiertenstipendien des kanadischen Medical Research Council unterstützt, K. R. Jarvie und Z. B. Pristupa erhielten ein Stipendium der Ontario Mental Health Foundation bzw. ein John-Cleghorn-Stipendium der Canadian Psychiatric Research Foundation. H. B. Niznik ist Wissenschaftler im Gesundheitsministerium von Ontario.

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Authors
  1. H. B. Niznik
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  2. R. K. Sunahara
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  3. Z. B. Pristupa
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  4. K. R. Jarvie
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Editors and Affiliations

  1. Dept. P & The Research Institute of Biological Psychiatry, Copenhagen Hospital Corporation, St. Hans Hospital, DK-4000, Roskilde, Dänemark

    Jes Gerlach M. D.

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© 1995 Springer-Verlag Berlin Heidelberg

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Niznik, H.B., Sunahara, R.K., Pristupa, Z.B., Jarvie, K.R. (1995). Molekulare Grundlagen der Interaktion zwischen Dopamin-(D1-/D2-)Rezeptoren. In: Gerlach, J. (eds) Schizophrenie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79738-5_1

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  • DOI: https://doi.org/10.1007/978-3-642-79738-5_1

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