Abstract
Heart failure is acompanied by a variety of compensatory mechanisms (e.g., sympathetic nervous system, renin-angiotensin-aldosterone, prostaglandin axis, vasopressin, atrial natriuretic peptide) affecting regional as well as central hemodynamics. In general, studies in animals and humans suggest that in congestive heart failure there is a redistribution of regional blood flow away from vascular beds sensitive to sympathetic stimulation (e.g., splanchnic, renal) with a relative increase in the proportion of cardiac output to the more autoregulated vascular beds such as the coronary and cerebral circulations. Regional blood flow measurements in previous studies have been restricted to one organ system and most often in the resting condition. Studies analyzing the regional distribution of cardiac output during maximal exercise in chronic stable heart failure are lacking.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Von Euler US (1936) On the specific vasodilating and plain muscle stimulating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin). J Physiol (Lond) 88:213–234
Vane JR (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol 231:235–237
Cowley AJ, Stainer K, Rowley JM, Hanley SP (1984) The effect of aspirin on peripheral haemodynamics changes following submaximal exercise in normal volunteers. Car- diovasc Res 18:511–513
Gerber JG (1983) Indomethacin-induced rises in blood pressure. Ann Intern Med 99:555–557
Cowley AJ, Stainer K, Rowley JM, Wilcox RG (1985) Effect of aspirin and indometah- cin on exercise induced changes in blood pressure and limb blood flow in normal volunteers. Cardiovasc Res 19:177–180
Nowak J, Wennmalm A (1978) Influence of indomethacin and of prostaglandin El on total and regional blood flow in man. Acta Physiol Scand 102:484–491
Mc Carthy SJ, Jones VE, Romero SC (1982) Acute intrinsic renal failure induced by indomethacin. Role of prostaglandin synthetase inhibition. Mayo Clin Proc 57:289–296
Punzengruber C, Stanek B, Sinzinger H, Silberbauer K (1986) Bicyclo-prostaglandin E2 metabolite in congestive heart failure and relation to vasoconstrictor neurohumoral principles. Am J Cardiol 57:619–623
Leithe ME, Margorien RD, Hermiller JB, Unverferth DV, Leier CV (1984) Relationship between central hemodynamics and regional blood flow in normal subjects and in patients with congestive heart failure. Circulation 69:57–64
Domingo E, Cardus D, McTaggart W (1985) Simultaneous central and peripheral cardiovascular impedance recordings. Automedica 6:193–208
Domingo E, Cardus D, Metaggart W (1987) Exercise cardiac output by the electrical impedance technique. Automedica 9:287–300
Packer M (1993) How should physicians view heart failure? The philosophical and physiological evolution of three conceptual models of the disease. Am J Cardiol 71:3C-11C
Townend J, Lote C, Littler W, Davies M (1993) Placebo controlled study of the effect of inhibition of prostaglandin synthesis with indomethacin on regional blood flow in- congestive heart failure (abstract). JACC 21:467A
Malik KU, McGiff JC (1976) Cardiovascular actions of prostaglandins. In: Karim SMM (ed) Prostaglandins: physiological, pharmacological and pathological aspects. MTP Press, Lancaster, pp 103–200
Gilabert MR, Ballester R, Soler-Soler J, Domingo E (1993) Influencia de la aspirina en la distribución regional del flujo sanguineo durante el ejercicio en la insuficiencia cardiaca (abstract). Rev Esp Cardiol 46 [Suppl I]:16
Gilabert MR, Domingo E, Soler-Soler J (1991) Aspirin and prostaglandin axis: effect on maximal exercise in healthy (abstract). Chest 100:S113
Staessen J, Cattaert A, Fagard R et al (1984) Hemodynamic and humoral effects of prostaglandin inhibition in exercising humans. J Appl Physiol 56 (1): 39–45
Domingo E, Gilabert MR, Alio J, Soler-Soler J (1991) Effect of drugs on a noninvasive index of arterial compliance in healthy and heart failure patients. Cathet Cardiovasc Diagn 24:93–98
Sanders TM, Werner A, Bloor M (1976) Visceral blood flow distribution during exercise to exhaustion in conscious dogs. J Appl Physiol 40:927–931
Finn WF, Arendshorst WJ (1976) Effect of prostaglandin synthetase inhibitors on renal blood flow in the rat. Am J Physiol 231:1541–1545
Chow CC, Alemayehu A, Mangino MJ (1989) Prostanoid in regulation of postprandial yeyunal hyperemia and oxygen uptake. Am J Physiol 257: G798-G808
Leier CV (1992) Regional blood flow in human congestive heart failure. Am Heart J 124(3): 726–738
Schwartz D, Kornowski R, Lehrman H et al (1992) Combined effect of Captopril ans aspirin in renal hemodynamics in elderly patients with congestive heart failure. Cardiology 81(6): 334–339
Ueyama M, Nishimura H, Kubota J, Kawamura K (1993) Hemodynamic and neurohumoral responses to exercise in patients with congestive heart failure. Jpn Circ J 57(5): 411–417
Zelis R, Flaim SF (1982) Alterations in vasomotor tone in congestive heart failure. Prog Cardiovasc Dis 24:437
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Domingo, E., Gilabert, M.R., Ballester, R. (1995). Effect of Aspirin on Central and Peripheral Cardiovascular Adaptation to Exercise in Heart Failure: Participation of Splanchnic Flow. In: Pinsky, M.R., Dhainaut, JF., Artigas, A. (eds) The Splanchnic Circulation. Update in Intensive Care and Emergency Medicine, vol 23. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79715-6_15
Download citation
DOI: https://doi.org/10.1007/978-3-642-79715-6_15
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-79717-0
Online ISBN: 978-3-642-79715-6
eBook Packages: Springer Book Archive