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Clinical and Molecular Advances in Acute Promyelocytic Leukaemia

  • Hugues de Thé
  • Laurent Degos
  • Raymond P. WarrellJr
Conference paper
Part of the ESO Monographs book series (ESO MONOGRAPHS)

Abstract

Acute promyelocytic leukaemia (APL) comprises approximately 10% of the acute myeloblastic leukaemias in adults [1,2]. The disease was first recognised as a distinctive clinical entity in the 1950s [3] and it typically presents with a severe bleeding diathesis that is exacerbated by chemotherapy [4–7]. This feature has led to a relatively high rate of early mortality, ranging from 8% to 47% in recent series [4–9], primarily as a consequence of intracranial haemorrhage [9–11]. In this chapter, we review the latest information regarding the molecular genetics and current methods of therapy of this disease.

Keywords

Retinoic Acid Disseminate Intravascular Coagulation Acute Promyelocytic Leukemia Minimal Residual Disease Retinoic Acid Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-verlag Berlin heidelberg 1995

Authors and Affiliations

  • Hugues de Thé
    • 1
  • Laurent Degos
    • 1
  • Raymond P. WarrellJr
    • 2
  1. 1.Hôpital St. LouisInstitut Universitaire d’HématologieParisFrance
  2. 2.Department of MedicineMemorial Sloan-Kettering Cancer CenterNew YorkUSA

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