Protein Kinase C and Lipid Signalling for Cellular Regulation

  • Shun-ichi Nakamura
  • Kouji Ogita
  • Yasutomi Nishizuka
  • Yoshinori Asaoka
  • Françoise Hullin
Conference paper
Part of the NATO ASI Series book series (volume 92)

Abstract

It is well documented that protein kinase C (PKC) is activated by increased levels of diacylglycerol (DG) in the membrane that is produced as a result of hydrolysis of inositol phospholipids (PI) by signal-induced activation of phospholipase C (PLC) (Nishizuka, 1992). Recently, attention has been paid to the hydrolysis of other phospholipids, particularly phosphatidylcholine (PC). This reaction produces DG at a relatively later phase in cellular responses, and possible involvement of phospholipase D (PLD) in PKC activation has been postulated (see for reviews: Billah & Anthes, 1990; Exton, 1990; Cockcroft, 1992). Sustained activation of PKC is a prerequisite essential for long-term responses such as cell proliferation and differentiation. In addition, phospholipase A2 (PLA2) is activated by most of the signals which induce PI hydrolysis. Arachidonic acid regulates many physiological processes after its conversion to various eicosanoids, but products of PC hydrolysis catalyzed by PLA2 potentiate PKC activation, thereby contributing to the signal transduction (Asaoka et al., 1992a). However, the biochemical mechanism of activation of phospholipases D and A2 remains largely unknown.

Keywords

Hydrolysis Dopamine Tyrosine Lipase Fluoride 

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References

  1. Ackermann EJ, Kempner ES and Dennis EA (1994) Ca2+− independent cytosolic phospholipase A2 from macrophage-like P388Di cells. J. Biol. Chem. 269: 9227–9233PubMedGoogle Scholar
  2. Akimoto K, Mizuno K, Osada S, Hirai S, Tanuma S, Suzuki K and Ohno S (1994) A new member of the third class in the protein kinase C family, PKCλ, expressed dominantly in an undifferentiated mouse embryonal cartinoma cell line and also in many tissues and cells. J. Biol. Chem. 269: in pressGoogle Scholar
  3. Anthes JC, Wang P, Siegel MI, Egan RW and Billah MM (1991) Granulocyte phospholipase D is activated by a guanine nucleotide dependent protein factor. Biochem. Biophys. Res. Commun. 175: 236–243PubMedCrossRefGoogle Scholar
  4. Asaoka Y, Oka M, Yoshida K and Nishizuka Y (1991) Metabolic rate of membrane-permeant diacylglycerol and its relation to human resting T-lymphocyte activation. Proc. Natl. Acad. Sci. USA 88: 8681–8685PubMedCrossRefGoogle Scholar
  5. Asaoka Y, Nakamura S, Yoshida K and Nishizuka Y. (1992a) Protein kinase C, calcium and phospholipid degradation. Trends Biochem. Sci. 17: 414–417PubMedCrossRefGoogle Scholar
  6. Asaoka Y, Oka M, Yoshida K, Sasaki Y and Nishizuka Y (1992b) Role of lysophosphatidylcholine in T-lymphocyte activation: Involvement of phospholipase A2 in signal transduction through protein kinase C. Proc. Natl. Acad. Sci. USA 89: 6447–6451PubMedCrossRefGoogle Scholar
  7. Asaoka Y, Yoshida K, Sasaki Y and Nishizuka Y (1993) Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation. Proc. Natl. Acad. Sci. USA 90: 4917–4921PubMedCrossRefGoogle Scholar
  8. Axelrod J, Burch RM and Jelsema CL (1988) Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers. Trends Neurosci. 11: 117–123PubMedCrossRefGoogle Scholar
  9. Bell RM and Burns DJ (1991) Lipid activation of protein kinase C. J. Biol. Chem. 266: 4661–4664PubMedGoogle Scholar
  10. Billah MM and Anthes JC (1990) The regulation and cellular functions of phosphatidylcholine hydrolysis. Biochem. J. 269: 281–291PubMedGoogle Scholar
  11. Blenis J (1993) Signal transduction via the MAP kinases: Proceed at your own RSK. Proc. Natl. Acad. Sci. USA 90: 5889–5892PubMedCrossRefGoogle Scholar
  12. Brown HA, Gutowski S, Moomaw CR, Slaughter C and Sternweis PC (1993) ADP-ribosylation factor, a small GTP-dependent regulatory protein, stimulates phospholipase D activity. Cell 75: 1137–1144PubMedCrossRefGoogle Scholar
  13. Chen SG and Murakami K (1992) Synergistic activation of type III protein kinase C by cis-fatty acid and diacylglycerol. Biochem. J. 282: 33–39PubMedGoogle Scholar
  14. Cockcroft S (1992) G-protein-regulated phospholipases D, D and A2-mediated signalling in neutrophils. Biochim. Biochys. Acta 1113: 135–160Google Scholar
  15. Cockcroft S, Thomas GMH, Fensome A, Geny B, Cunningham E, Gout I, Hiles I, Totty NF, Truong O and Hsuan JJ (1994) Phospholipase D: a downstream effector of ARF in granulocytes. Science 263: 523–526PubMedCrossRefGoogle Scholar
  16. Cuadrado A, Carnero A, Dolfi F, Jiménez B and Lacal JC (1993) Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors. Oncogene 8: 2959–2968PubMedGoogle Scholar
  17. Dekker LV and Parker PJ (1994) Protein kinase C —a question of specificity. Trends Biochem. Sci. 19: 73–77PubMedCrossRefGoogle Scholar
  18. Denning MF, Dlugosz AA, Howett MK and Yuspa SH (1993) Expression of an oncogenic rasHa gene in murine keratinocytes induces tyrosine phosphorylation and reduced activity of protein kinase C δ. J. Biol. Chem. 268: 26079–26081PubMedGoogle Scholar
  19. Dennis EA, Rhee SG, Billah MM and Hannun YA (1991) Role of phospholipases in generating lipid second messengers in signal transduction. FASEB J 5: 2068–2077PubMedGoogle Scholar
  20. Downward J, Graves JD, Warne PH, Rayter S and Cantrell DA (1990) Stimulation of p21ras upon T-cell activation. Nature (London) 346: 719–723PubMedCrossRefGoogle Scholar
  21. Exton JH (1990) Signaling through phosphatidylcholine breakdown. J. Biol. Chem. 265: 1–4PubMedGoogle Scholar
  22. Harwood AE and Cambier J (1993) B cell antigen receptor cross-linking triggers rapid protein kinase C independent activation of p21rasl. J. Immunol. 151: 4513–4522PubMedGoogle Scholar
  23. Hordijk PL, Verlaan I, van Corven EJ and Moolenaar WH (1994) Protein tyrosine phosphorylation induced by lysophosphatidic acid in rat-1 fibroblasts. Evidence that phosphorylation of MAP kinase is mediated by the Gi-p2lras pathway. J. Biol. Chem. 269: 645–651PubMedGoogle Scholar
  24. Hug H and Sarre TF (1993) Protein kinase C isoenzymes: divergence in signal transduction? Biochem. J. 291: 329–343PubMedGoogle Scholar
  25. Ikuta T, Chida K, Tajima 0, Matsuura Y, Iwamori M, Ueda Y, Mizuno K, Ohno S and Kuroki T (1994) Cholesterol sulfate, a novel activator for the η isoform of protein kinase C. Cell Growth & Differentiation: in pressGoogle Scholar
  26. Johannes F-J, Prestle J, Eis S, Oberhagemann P and Pfizenmaier K (1994) PKCu is a novel, atypical member of the protein kinase C family. J. Biol. Chem. 269: 6140–6148PubMedGoogle Scholar
  27. Kolch W, Heidecker G, Kochs G, Hummel R, Vahidi H, Mischak H, Finkenzeller G, Marme D, and Rapp UR (1993) Protein kinase Ca activates Raf-1 by direct phosphorylation. Nature (London) 364: 249–252PubMedCrossRefGoogle Scholar
  28. Kramer RM, Roberts EF, Manetta JV, Hyslop PA and Jakubowski J.A. (1993) Thrombin-induced phosphorylation and activation of Ca2+-sensitive cytosolic phospholipase A2 in human platelets. J. Biol. Chem. 268: 26796–26804PubMedGoogle Scholar
  29. Kusner DJ, Schomisch SJ and Dubyak GR (1993) ATP-induced potentiation of G-protein-dependent phospholipase D activity in cell-free system from U937 promonocytic leukocytes. J. Biol. Chem. 267: 19973–19982Google Scholar
  30. Lange-Carter CA, Pleiman CM, Gardner AM, Blumer KJ, and Johnson GL (1993) A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 260: 315–319PubMedCrossRefGoogle Scholar
  31. Li W, Mischak H, Yu J-C, Wang L-M, Mushinski JF, Heidaran MA and Pierce JH (1994) Tyrosine phosphorylation of protein kinase C-6 in response to its activation. J. Biol. Chem. 269: 2349–2352PubMedGoogle Scholar
  32. Liscovitch M (1992) Crosstalk among multiple signal-activated phospholipases. Trends Biochem._Sci. 17: 393–399PubMedCrossRefGoogle Scholar
  33. Lin L-L, Wartmann M, Lin AY, Knopt JL, Seth A and Davis RJ (1993) CPLA2 is phosphorylated and activated by MAP kinase. Cell 72: 269–278PubMedCrossRefGoogle Scholar
  34. MacDonald SG, Crews CM, Wu L, Driller J, Clark R, Erikson RL and McCormick F (1993) Reconstitution of the Raf-1—MEK—ERK signal transduction pathway in vitro. Mol. Cell. Biol. 13: 6615–6620PubMedGoogle Scholar
  35. Newton AC (1993) Interaction of proteins with lipid head groups: lessons from protein kinase C. Annu. Rev. Biophys. Biomol. Struct. 22: 1–25PubMedCrossRefGoogle Scholar
  36. Nishida E and Gotoh Y (1993) The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem. Sci. 18: 128–131Google Scholar
  37. Nishizuka Y (1986) Studies and perspectives of protein kinase C. Science 233: 305–312PubMedCrossRefGoogle Scholar
  38. Nishizuka Y (1988) The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature (London) 334: 661–665PubMedCrossRefGoogle Scholar
  39. Nishizuka Y (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258: 607–614PubMedCrossRefGoogle Scholar
  40. Olson SC, Bowman EP and Lambeth JD (1991) Phospholipase D activation in a cell-free system from human neutrophils by phorbol 12-myristate 13-acetate and guanosine 5’-O-(3-thiotriphosphate) J. Biol. Chem. 266: 17236–17242PubMedGoogle Scholar
  41. Quest AFG, Bardes ESG and Bell RM (1994) A phorbol ester binding domain of protein kinase Cy. Deletion analysis of the cys2 domain defines a minimal 43-amino acid peptide. J. Biol. Chem. 269: 2961–2970PubMedGoogle Scholar
  42. Selbie LA, Schmitz-Peiffer C, Sheng Y and Biden TJ (1993) Molecular cloning and characterization of PKCl, an atypical isoform of protein kinase C derived from insulin-secreting cells. J. Biol. Chem. 268: 24296–24302PubMedGoogle Scholar
  43. Shinomura T, Asaoka Y, Oka M, Yoshida K and Nishizuka Y (1991) Synergistic action of diacylglycerol and unsaturated fatty acid for protein kinase C activation: Its possible implications. Proc. Natl. Acad. Sci. USA 88: 5149–5153PubMedCrossRefGoogle Scholar
  44. Tsujishita Y, Asaoka Y and Nishizuka Y (1994) Regulation of phospholipase A2 in human leukemia cell lines: its implication for intracellular signaling. Proc. Natl. Acad. Sci. USA 91: 6274–6278PubMedCrossRefGoogle Scholar
  45. Yoshida K, Asaoka Y and Nishizuka Y (1992) Platelet activation by simultaneous actions of diacylglycerol and unsaturated fatty acids. Proc. Natl. Acad. Sci. USA 89: 6443–6446PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Shun-ichi Nakamura
    • 1
  • Kouji Ogita
    • 1
  • Yasutomi Nishizuka
    • 1
  • Yoshinori Asaoka
    • 2
  • Françoise Hullin
    • 2
  1. 1.Department of BiochemistryKobe University School of MedicineKobe 650Japan
  2. 2.Biosignal Research CenterKobe UniversityKobe 657Japan

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