Biokinetics of Vitamin E in Lipoproteins and Cells
The paper will describe 1) the various naturally occurring and synthetic forms of vitamin E, 2) lipoprotein metabolism as it relates to plasma vitamin E transport, 3) the mechanism for the preferential enrichment of plasma and tissues with only one form of vitamin E, namely RRR-α—tocopherol, 4) kinetic estimates of the turnover of vitamin E in human plasma and 5) determinants of vitamin E tissue concentrations.
KeywordsHigh Density Lipoprotein Plasma Vitamin Tocopherol Concentration Friedreich Ataxia Tocopheryl Acetate
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- Baker, H, Handelman, GJ, Short, S, Machlin, LJ, Bhagavan, HN, Dratz, EA, Frank, O (1986) Comparison of plasma α- and γ-tocopherol levels following chronic oral administration of either all-rac-α-tocopheryl acetate or RRR-α-tocopheryl acetate in normal adult male subjects. Am. J. Clin. Nutr. 43: 382–387.PubMedGoogle Scholar
- Ben Hamida, C, Doerflinger, N, Belal, S, Linder, C, Reutenauer, L, Dib, C, Gyapay, G, Bignal, A, Le Paslier, D, Cohen, D, Pandolfo, M, Mokini, V, Novelli, G, Hentati, F, Ben Hamida, M, Mandel, JL, Koenig, M (1993a) Localization of Friedreich ataxia phenotype with selective vitamin E deficiency to chromosome 8q by homozygosity mapping. Nature Genetics 5: 195–200.PubMedCrossRefGoogle Scholar
- Ben Hamida, M, Belal, S, Sirugo, G (1993b) Friedreich’s ataxia phenotype not linked to chromosome 9 and associated with selective autosomal recessive vitamin E deficiency in two inbred Tunisian families. Neurology 2179–2183.Google Scholar
- Burton, GW, Wronska, U, Stone, L, Foster, DO, Ingold, KU (1990b) Biokinetics of dietary RRR-α-tocopherol in the male guinea pig at three dietary levels of vitamin C and two levels of vitamin E. Evidence that vitamin C does not “spare” vitamin E in vivo. Lipids 25: 199–210.PubMedCrossRefGoogle Scholar
- McCormiek, EC, Cornwell, DG, Brown, JB (1960) Studies on the distribution of tocopherol in human serum lipoproteins. J. Lipid Res. 1: 221–228.Google Scholar
- Sokol, RJ (1993). Vitamin E deficiency and neurological disorders. Vitamin E in Health and Disease, Packer, L, Fuchs, J, eds. New York, NY, Marcel Dekker, Inc. 815–849.Google Scholar
- Traber, MG, Burton, GW, Ingold, KU, Kayden, HJ (1990a) RRR- and SRR-α-tocopherols are secreted without discrimination in human chylomicrons, but RRR-α-tocopherol is preferentially secreted in very low density lipoproteins. J. Lipid Res. 31: 675–685.Google Scholar
- Traber, MG, Kayden, HJ, Green, JB, Green, MH (1986) Absorption of water miscible forms of vitamin E in a patient with cholestasis and in rats. Am. J. Clin. Nun. 44: 914–923.Google Scholar
- Traber, MG, Ramakrishnan, R, Kayden, HJ (1994) Human plasma vitamin E kinetics demonstrate rapid recycling of plasma RRR-α-tocopherol. Proc. Natl. Acad. Sci. USA In Press.Google Scholar
- Traber, MG, Sokol, RJ, Kohlschütter, A, Yokota, T, Muller, DPR, Dufour, R, Kayden, HJ (1993b) Impaired discrimination between stereoisomers of α-tocopherol in patients with familial isolated vitamin E deficiency. J. Lipid Res. 34: 201–210.Google Scholar
- Weiser, H, Vecchi, M, Schlachter, M (1986) Stereoisomers of α-tocopheryl acetate. IV. USP units and a-tocopherol equivalents ofall-rac-, 2-ambo- and RRR-α-tocopherol evaluated by simultaneous determination of resorption-gestation, myopathy and liver storage capacity in rats. Int. J. Vit. Nutr. Res. 56: 45–56.Google Scholar